BAIT
DAO
Dao1
D-amino-acid oxidase
GO Process (6)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
ANK2
Ank3
ankyrin 2, neuronal
GO Process (40)
GO Function (9)
GO Component (18)
Gene Ontology Biological Process
- SA node cell action potential [ISO]
- SA node cell to atrial cardiac muscle cell communication [ISO]
- T-tubule organization [ISO]
- atrial cardiac muscle cell action potential [ISO]
- atrial cardiac muscle cell to AV node cell communication [ISO]
- atrial septum development [ISO]
- cardiac muscle contraction [ISO]
- cellular calcium ion homeostasis [ISO]
- cellular protein localization [ISO]
- nervous system development [IEP]
- paranodal junction assembly [IEP]
- positive regulation of calcium ion transmembrane transporter activity [ISO]
- positive regulation of calcium ion transport [ISO]
- positive regulation of cation channel activity [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of potassium ion transmembrane transporter activity [ISO]
- positive regulation of potassium ion transport [ISO]
- protein localization [ISO]
- protein localization to M-band [ISO]
- protein localization to T-tubule [ISO]
- protein localization to cell surface [ISO]
- protein localization to endoplasmic reticulum [ISO]
- protein localization to organelle [ISO]
- protein localization to plasma membrane [ISO]
- protein stabilization [ISO]
- protein targeting to plasma membrane [ISO]
- regulation of calcium ion transmembrane transporter activity [ISO]
- regulation of calcium ion transport [ISO]
- regulation of cardiac muscle cell contraction [ISO]
- regulation of cardiac muscle cell membrane potential [ISO]
- regulation of cardiac muscle contraction [ISO]
- regulation of cardiac muscle contraction by calcium ion signaling [ISO]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [ISO]
- regulation of cation channel activity [ISO]
- regulation of heart rate [ISO]
- regulation of heart rate by cardiac conduction [ISO]
- regulation of release of sequestered calcium ion into cytosol [ISO]
- regulation of ventricular cardiac muscle cell membrane repolarization [ISO]
- response to methylmercury [IEP]
- ventricular cardiac muscle cell action potential [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- A band [ISO]
- M band [ISO]
- T-tubule [ISO]
- Z disc [ISO]
- basolateral plasma membrane [ISO]
- cell [ISO]
- costamere [ISO]
- cytoplasm [ISO]
- cytoskeleton [IDA]
- integral component of plasma membrane [ISO]
- intercalated disc [ISO]
- intracellular [ISO]
- membrane raft [IDA]
- neuron projection [IDA]
- neuronal postsynaptic density [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- sarcolemma [ISO]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.
Schizophrenia is a highly heritable neuropsychiatric disorder affecting ∼1% of the world's population. Linkage and association studies have identified multiple candidate schizophrenia susceptibility genes whose functions converge on the glutamatergic neurotransmitter system. One such susceptibility gene encoding D-amino acid oxidase (DAO), an enzyme that metabolizes the NMDA receptor (NMDAR) co-agonist D-serine, has the potential to modulate NMDAR function in the ... [more]
J. Biol. Chem. Aug. 19, 2011; 286(33);28867-75 [Pubmed: 21700703]
Throughput
- Low Throughput
Curated By
- BioGRID