BAIT
DAO
Dao1
D-amino-acid oxidase
GO Process (6)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
STOML2
stomatin (Epb7.2)-like 2
GO Process (15)
GO Function (1)
GO Component (11)
Gene Ontology Biological Process
- CD4-positive, alpha-beta T cell activation [ISO, ISS]
- T cell receptor signaling pathway [ISO, ISS]
- cellular calcium ion homeostasis [ISO, ISS]
- interleukin-2 production [ISO, ISS]
- lipid localization [ISO, ISS]
- mitochondrial ATP synthesis coupled proton transport [ISO, ISS]
- mitochondrial calcium ion transport [ISO, ISS]
- mitochondrial protein processing [ISO, ISS]
- mitochondrion localization [ISO]
- mitochondrion organization [ISO, ISS]
- positive regulation of cardiolipin metabolic process [ISO, ISS]
- positive regulation of mitochondrial DNA replication [ISO, ISS]
- positive regulation of mitochondrial membrane potential [ISO, ISS]
- protein oligomerization [ISO, ISS]
- stress-induced mitochondrial fusion [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- COP9 signalosome [ISO]
- T cell receptor complex [ISO, ISS]
- actin cytoskeleton [ISO, ISS]
- cell [ISO]
- extrinsic component of plasma membrane [ISO, ISS]
- immunological synapse [ISO, ISS]
- intracellular [ISO]
- membrane raft [ISO, ISS]
- mitochondrial inner membrane [ISO, ISS]
- mitochondrial intermembrane space [ISO, ISS]
- mitochondrion [ISO]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.
Schizophrenia is a highly heritable neuropsychiatric disorder affecting ∼1% of the world's population. Linkage and association studies have identified multiple candidate schizophrenia susceptibility genes whose functions converge on the glutamatergic neurotransmitter system. One such susceptibility gene encoding D-amino acid oxidase (DAO), an enzyme that metabolizes the NMDA receptor (NMDAR) co-agonist D-serine, has the potential to modulate NMDAR function in the ... [more]
J. Biol. Chem. Aug. 19, 2011; 286(33);28867-75 [Pubmed: 21700703]
Throughput
- Low Throughput
Curated By
- BioGRID