BAIT
DAO
Dao1
D-amino-acid oxidase
GO Process (6)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
RAP1B
RAP1B, member of RAS oncogene family
GO Process (10)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- Rap protein signal transduction [ISO, ISS]
- cell proliferation [ISO]
- cellular response to cAMP [ISO, ISS]
- establishment of endothelial barrier [ISO, ISS]
- negative regulation of calcium ion-dependent exocytosis [ISO]
- negative regulation of synaptic vesicle exocytosis [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- regulation of cell junction assembly [ISO, ISS]
- regulation of establishment of cell polarity [ISO, ISS]
- small GTPase mediated signal transduction [ISO]
Gene Ontology Molecular Function- GDP binding [ISO, ISS]
- GTP binding [ISO, ISS, TAS]
- GTPase activity [ISO, ISS, TAS]
- protein complex binding [ISO]
- GDP binding [ISO, ISS]
- GTP binding [ISO, ISS, TAS]
- GTPase activity [ISO, ISS, TAS]
- protein complex binding [ISO]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.
Schizophrenia is a highly heritable neuropsychiatric disorder affecting ∼1% of the world's population. Linkage and association studies have identified multiple candidate schizophrenia susceptibility genes whose functions converge on the glutamatergic neurotransmitter system. One such susceptibility gene encoding D-amino acid oxidase (DAO), an enzyme that metabolizes the NMDA receptor (NMDAR) co-agonist D-serine, has the potential to modulate NMDAR function in the ... [more]
J. Biol. Chem. Aug. 19, 2011; 286(33);28867-75 [Pubmed: 21700703]
Throughput
- Low Throughput
Curated By
- BioGRID