BAIT
DAO
Dao1
D-amino-acid oxidase
GO Process (6)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
RTN4
NI-250, Nogo, Nogo-A, Vp20, r, rat N, rat NogoA
reticulon 4
GO Process (23)
GO Function (3)
GO Component (14)
Gene Ontology Biological Process
- aging [IEP]
- angiogenesis [ISO]
- axonal fasciculation [IDA, ISO]
- cardiac epithelial to mesenchymal transition [ISO]
- cerebral cortex radial glia guided migration [ISO, ISS]
- endoplasmic reticulum tubular network organization [ISO]
- negative regulation of axon extension [IDA, ISO, ISS]
- negative regulation of axonogenesis [IDA, IMP]
- negative regulation of cell growth [ISO]
- negative regulation of neuron differentiation [IDA]
- negative regulation of neuron projection development [IDA]
- negative regulation of neuron projection regeneration [IMP]
- nervous system development [ISO]
- olfactory nerve development [IEP]
- oligodendrocyte differentiation [IEP]
- positive regulation of dopamine secretion [IMP]
- positive regulation of glial cell differentiation [IDA]
- regulation of axon regeneration [IDA]
- regulation of branching morphogenesis of a nerve [IDA, ISO]
- regulation of cell migration [ISO]
- regulation of nervous system development [ISO]
- regulation of sensory perception of pain [IDA]
- response to activity [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell projection [ISO]
- cytoplasm [IDA]
- endoplasmic reticulum [IDA, ISO]
- extracellular vesicular exosome [ISO]
- integral component of endoplasmic reticulum membrane [IDA, ISO]
- integral component of membrane [TAS]
- intracellular [IDA, ISO]
- myelin sheath [IDA]
- neuron projection [IDA]
- neuronal cell body [IDA, ISO]
- neuronal postsynaptic density [ISO]
- nuclear envelope [ISO, ISS]
- plasma membrane [IDA]
- protein complex [IDA]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.
Schizophrenia is a highly heritable neuropsychiatric disorder affecting ∼1% of the world's population. Linkage and association studies have identified multiple candidate schizophrenia susceptibility genes whose functions converge on the glutamatergic neurotransmitter system. One such susceptibility gene encoding D-amino acid oxidase (DAO), an enzyme that metabolizes the NMDA receptor (NMDAR) co-agonist D-serine, has the potential to modulate NMDAR function in the ... [more]
J. Biol. Chem. Aug. 19, 2011; 286(33);28867-75 [Pubmed: 21700703]
Throughput
- Low Throughput
Curated By
- BioGRID