PREY

RTN4

NI-250, Nogo, Nogo-A, Vp20, r, rat N, rat NogoA
reticulon 4
GO Process (23)
GO Function (3)
GO Component (14)
Rattus norvegicus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.

Popiolek M, Ross JF, Charych E, Chanda P, Gundelfinger ED, Moss SJ, Brandon NJ, Pausch MH

Schizophrenia is a highly heritable neuropsychiatric disorder affecting ∼1% of the world's population. Linkage and association studies have identified multiple candidate schizophrenia susceptibility genes whose functions converge on the glutamatergic neurotransmitter system. One such susceptibility gene encoding D-amino acid oxidase (DAO), an enzyme that metabolizes the NMDA receptor (NMDAR) co-agonist D-serine, has the potential to modulate NMDAR function in the ... [more]

J. Biol. Chem. Aug. 19, 2011; 286(33);28867-75 [Pubmed: 21700703]

Throughput

  • Low Throughput

Curated By

  • BioGRID