BAIT
DAO
Dao1
D-amino-acid oxidase
GO Process (6)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
THY1
CD7
Thy-1 cell surface antigen
GO Process (18)
GO Function (6)
GO Component (14)
Gene Ontology Biological Process
- T cell receptor signaling pathway [IMP]
- angiogenesis [ISO, ISS]
- cytoskeleton organization [IDA]
- focal adhesion assembly [IDA]
- mast cell activation [NAS]
- negative regulation of T cell receptor signaling pathway [ISO, ISS]
- negative regulation of apoptotic process [TAS]
- negative regulation of axonogenesis [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of fibroblast proliferation [NAS]
- negative regulation of protein kinase activity [IDA]
- positive regulation of GTPase activity [IDA]
- positive regulation of Rho GTPase activity [IDA]
- positive regulation of T cell activation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [NAS]
- positive regulation of release of sequestered calcium ion into cytosol [IDA]
- retinal cone cell development [ISO, ISS]
- single organismal cell-cell adhesion [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- anchored component of external side of plasma membrane [ISO]
- anchored component of plasma membrane [IDA]
- apical plasma membrane [ISO]
- cell surface [IDA, TAS]
- cytosol [IDA]
- dendrite [ISO]
- endoplasmic reticulum [ISO]
- external side of plasma membrane [ISO, ISS]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- growth cone [IDA]
- membrane raft [ISO]
- myelin sheath [ISO]
- plasma membrane [IDA]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.
Schizophrenia is a highly heritable neuropsychiatric disorder affecting ∼1% of the world's population. Linkage and association studies have identified multiple candidate schizophrenia susceptibility genes whose functions converge on the glutamatergic neurotransmitter system. One such susceptibility gene encoding D-amino acid oxidase (DAO), an enzyme that metabolizes the NMDA receptor (NMDAR) co-agonist D-serine, has the potential to modulate NMDAR function in the ... [more]
J. Biol. Chem. Aug. 19, 2011; 286(33);28867-75 [Pubmed: 21700703]
Throughput
- Low Throughput
Curated By
- BioGRID