BAIT
DAO
Dao1
D-amino-acid oxidase
GO Process (6)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
MAOB
monoamine oxidase B
GO Process (12)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- negative regulation of serotonin secretion [IMP]
- neurotransmitter catabolic process [IDA, TAS]
- positive regulation of dopamine metabolic process [IMP]
- response to aluminum ion [IEP]
- response to corticosterone [IEP]
- response to drug [IEP]
- response to ethanol [IEP]
- response to lipopolysaccharide [IEP]
- response to selenium ion [IEP]
- response to steroid hormone [IEP]
- response to toxic substance [IEP]
- substantia nigra development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.
Schizophrenia is a highly heritable neuropsychiatric disorder affecting ∼1% of the world's population. Linkage and association studies have identified multiple candidate schizophrenia susceptibility genes whose functions converge on the glutamatergic neurotransmitter system. One such susceptibility gene encoding D-amino acid oxidase (DAO), an enzyme that metabolizes the NMDA receptor (NMDAR) co-agonist D-serine, has the potential to modulate NMDAR function in the ... [more]
J. Biol. Chem. Aug. 19, 2011; 286(33);28867-75 [Pubmed: 21700703]
Throughput
- Low Throughput
Curated By
- BioGRID