BAIT
DAO
Dao1
D-amino-acid oxidase
GO Process (6)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
OGT
O-linked N-acetylglucosamine (GlcNAc) transferase
GO Process (41)
GO Function (12)
GO Component (13)
Gene Ontology Biological Process
- apoptotic process [ISO, ISS]
- cellular response to glucose stimulus [IMP]
- cellular response to insulin stimulus [IEP]
- cellular response to lipopolysaccharide [IMP]
- cellular response to retinoic acid [ISO]
- cellular response to toxic substance [IEP]
- circadian regulation of gene expression [ISO, ISS]
- forebrain development [IEP]
- glucosamine metabolic process [IDA, IMP]
- histone H3-K4 trimethylation [ISO, ISS]
- histone H4-K16 acetylation [ISO, ISS]
- histone H4-K5 acetylation [ISO, ISS]
- histone H4-K8 acetylation [ISO, ISS]
- intracellular distribution of mitochondria [IMP]
- negative regulation of cell death [IMP]
- negative regulation of cellular response to hypoxia [IMP]
- negative regulation of peptidyl-serine phosphorylation [IMP]
- negative regulation of peptidyl-threonine phosphorylation [IMP]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of protein targeting to membrane [IMP]
- negative regulation of protein ubiquitination [ISO, ISS]
- phosphatidylinositol-mediated signaling [ISO, ISS]
- positive regulation of catalytic activity [ISO]
- positive regulation of cell size [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of granulocyte differentiation [ISO]
- positive regulation of histone H3-K27 methylation [ISO, ISS]
- positive regulation of histone H3-K4 methylation [ISO]
- positive regulation of protein localization to nucleus [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of proteolysis [ISO, ISS]
- positive regulation of reactive oxygen species biosynthetic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- protein O-linked glycosylation [IDA, IMP, ISO]
- protein heterotrimerization [IDA]
- protein homotrimerization [IDA]
- regulation of Rac protein signal transduction [ISO]
- regulation of gluconeogenesis involved in cellular glucose homeostasis [ISO, ISS]
- regulation of glycolytic process [ISO, ISS]
- regulation of insulin receptor signaling pathway [ISO]
- response to insulin [ISO]
Gene Ontology Molecular Function- enzyme activator activity [ISO]
- histone acetyltransferase activity (H4-K16 specific) [ISO, ISS]
- histone acetyltransferase activity (H4-K5 specific) [ISO, ISS]
- histone acetyltransferase activity (H4-K8 specific) [ISO, ISS]
- monosaccharide binding [IDA]
- peptide binding [IDA]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO, ISS]
- protein N-acetylglucosaminyltransferase activity [IDA, ISO]
- protein O-GlcNAc transferase activity [ISO, ISS]
- protein binding [IPI]
- protein domain specific binding [IPI]
- transcription factor binding [IPI]
- enzyme activator activity [ISO]
- histone acetyltransferase activity (H4-K16 specific) [ISO, ISS]
- histone acetyltransferase activity (H4-K5 specific) [ISO, ISS]
- histone acetyltransferase activity (H4-K8 specific) [ISO, ISS]
- monosaccharide binding [IDA]
- peptide binding [IDA]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO, ISS]
- protein N-acetylglucosaminyltransferase activity [IDA, ISO]
- protein O-GlcNAc transferase activity [ISO, ISS]
- protein binding [IPI]
- protein domain specific binding [IPI]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
- MLL5-L complex [ISO]
- cytoplasm [IDA, ISO]
- cytosol [IDA, ISO]
- euchromatin [IDA]
- histone acetyltransferase complex [ISO, ISS]
- microtubule organizing center [ISO]
- mitochondrion [IDA]
- neuron projection [IDA]
- neuronal cell body [IDA]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- plasma membrane [ISO, ISS]
- zymogen granule [IDA]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.
Schizophrenia is a highly heritable neuropsychiatric disorder affecting ∼1% of the world's population. Linkage and association studies have identified multiple candidate schizophrenia susceptibility genes whose functions converge on the glutamatergic neurotransmitter system. One such susceptibility gene encoding D-amino acid oxidase (DAO), an enzyme that metabolizes the NMDA receptor (NMDAR) co-agonist D-serine, has the potential to modulate NMDAR function in the ... [more]
J. Biol. Chem. Aug. 19, 2011; 286(33);28867-75 [Pubmed: 21700703]
Throughput
- Low Throughput
Curated By
- BioGRID