BAIT
DAO
Dao1
D-amino-acid oxidase
GO Process (6)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
UNC13A
Munc13-1, Unc13h1
unc-13 homolog A (C. elegans)
GO Process (11)
GO Function (7)
GO Component (8)
Gene Ontology Biological Process
- beta-amyloid metabolic process [ISO]
- innervation [ISO]
- long-term synaptic potentiation [IMP]
- neuromuscular junction development [ISO]
- neurotransmitter secretion [IDA]
- positive regulation of neurotransmitter secretion [ISO]
- regulation of short-term neuronal synaptic plasticity [ISO]
- synaptic transmission, glutamatergic [ISO]
- synaptic vesicle docking [ISO]
- synaptic vesicle maturation [ISO]
- synaptic vesicle priming [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.
Schizophrenia is a highly heritable neuropsychiatric disorder affecting ∼1% of the world's population. Linkage and association studies have identified multiple candidate schizophrenia susceptibility genes whose functions converge on the glutamatergic neurotransmitter system. One such susceptibility gene encoding D-amino acid oxidase (DAO), an enzyme that metabolizes the NMDA receptor (NMDAR) co-agonist D-serine, has the potential to modulate NMDAR function in the ... [more]
J. Biol. Chem. Aug. 19, 2011; 286(33);28867-75 [Pubmed: 21700703]
Throughput
- Low Throughput
Curated By
- BioGRID