DAB2IP
Gene Ontology Biological Process
- I-kappaB phosphorylation [ISS]
- activation of JUN kinase activity [IDA]
- activation of MAPKKK activity [IDA]
- cell motility involved in cerebral cortex radial glia guided migration [ISS]
- cellular protein catabolic process [IDA]
- cellular response to epidermal growth factor stimulus [ISS]
- cellular response to interleukin-1 [IDA]
- cellular response to lipopolysaccharide [IDA]
- cellular response to tumor necrosis factor [IDA]
- cellular response to vascular endothelial growth factor stimulus [IDA, ISS]
- endothelial cell apoptotic process [TAS]
- extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]
- layer formation in cerebral cortex [ISS]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of G0 to G1 transition [IDA]
- negative regulation of GTPase activity [ISS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of MAP kinase activity [IDA, IMP]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of Ras GTPase activity [IMP]
- negative regulation of Ras protein signal transduction [IBA, IC]
- negative regulation of angiogenesis [IDA]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of catenin import into nucleus [ISS]
- negative regulation of cell proliferation [IDA]
- negative regulation of cyclin catabolic process [IDA]
- negative regulation of endothelial cell migration [IMP]
- negative regulation of epidermal growth factor receptor signaling pathway [ISS]
- negative regulation of epithelial cell migration [IMP, TAS]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of epithelial to mesenchymal transition [IDA, IMP]
- negative regulation of fibroblast proliferation [ISS]
- negative regulation of phosphatidylinositol 3-kinase activity [IDA]
- negative regulation of phosphatidylinositol 3-kinase signaling [IDA]
- negative regulation of protein phosphorylation [IMP, ISS]
- negative regulation of protein serine/threonine kinase activity [IDA, IMP]
- negative regulation of toll-like receptor 4 signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [IMP]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [IMP]
- negative regulation of vascular endothelial growth factor signaling pathway [ISS]
- neuron projection morphogenesis [ISS]
- positive regulation of JNK cascade [IDA]
- positive regulation of JUN kinase activity [IDA]
- positive regulation of MAPK cascade [IDA]
- positive regulation of Ras GTPase activity [IBA]
- positive regulation of apoptotic process [IDA]
- positive regulation of apoptotic signaling pathway [IDA]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of dendrite development [ISS]
- positive regulation of neuron migration [ISS]
- positive regulation of neuron projection development [ISS]
- positive regulation of proteasomal protein catabolic process [IMP]
- positive regulation of protein catabolic process [ISS]
- positive regulation of protein serine/threonine kinase activity [IDA, IMP]
- positive regulation of synapse maturation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of ARF GTPase activity [ISS]
- regulation of I-kappaB kinase/NF-kappaB signaling [ISS]
- regulation of p38MAPK cascade [ISS]
- regulation of protein complex assembly [IDA]
- transformed cell apoptotic process [TAS]
- tube formation [IMP]
- vascular endothelial growth factor receptor-2 signaling pathway [ISS]
Gene Ontology Molecular Function- 14-3-3 protein binding [IDA]
- Ras GTPase activator activity [IBA, ISS]
- SH3 domain binding [IDA]
- Toll-like receptor 4 binding [IDA]
- death receptor binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- mitogen-activated protein kinase kinase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- phosphatidylinositol 3-kinase binding [IDA]
- phosphatidylinositol 3-kinase regulatory subunit binding [IDA]
- phosphatidylinositol-3-phosphate binding [IDA]
- phosphatidylinositol-4-phosphate binding [IDA]
- protein binding [IPI]
- protein complex binding [IDA]
- protein homodimerization activity [IPI]
- protein kinase binding [IPI]
- protein phosphatase 2A binding [IDA]
- signaling adaptor activity [IDA]
- vascular endothelial growth factor receptor 2 binding [IPI]
- 14-3-3 protein binding [IDA]
- Ras GTPase activator activity [IBA, ISS]
- SH3 domain binding [IDA]
- Toll-like receptor 4 binding [IDA]
- death receptor binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- mitogen-activated protein kinase kinase binding [IPI]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- phosphatidylinositol 3-kinase binding [IDA]
- phosphatidylinositol 3-kinase regulatory subunit binding [IDA]
- phosphatidylinositol-3-phosphate binding [IDA]
- phosphatidylinositol-4-phosphate binding [IDA]
- protein binding [IPI]
- protein complex binding [IDA]
- protein homodimerization activity [IPI]
- protein kinase binding [IPI]
- protein phosphatase 2A binding [IDA]
- signaling adaptor activity [IDA]
- vascular endothelial growth factor receptor 2 binding [IPI]
Gene Ontology Cellular Component
- axon [ISS]
- cerebellar mossy fiber [ISS]
- climbing fiber [ISS]
- cytoplasm [IDA]
- endocytic vesicle [IDA]
- extracellular vesicular exosome [IDA]
- intrinsic component of the cytoplasmic side of the plasma membrane [IBA]
- neuronal cell body [ISS]
- neuronal cell body membrane [ISS]
- parallel fiber [ISS]
- plasma membrane [IDA]
MAP3K5
Gene Ontology Biological Process
- JNK cascade [IDA]
- MAPK cascade [IDA]
- activation of JUN kinase activity [TAS]
- activation of MAPKK activity [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- apoptotic signaling pathway [TAS]
- cellular response to hydrogen peroxide [IDA]
- intrinsic apoptotic signaling pathway in response to oxidative stress [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of neuron death [IGI]
- protein phosphorylation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Amyloid β regulates the expression and function of AIP1.
Apoptosis signal-regulating kinase 1-interacting (ASK1-interacting) protein-1 (AIP1) is a newly identified novel member of the Ras GTPase-activating protein family, which has been implicated in cell growth inhibition and cell apoptosis. However, the effects of AIP1 in Alzheimer's disease (AD) are unknown. In the present study, we found that AIP1 was elevated in the brain of AD Tg2576 mice and Aβ1-42 ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MAP3K5 DAB2IP | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 870305 | |
| DAB2IP MAP3K5 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 870307 | |
| DAB2IP MAP3K5 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| MAP3K5 DAB2IP | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| MAP3K5 DAB2IP | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID