Glioblastoma multiforme (GBM) is an extremely aggressive brain cancer with a median survival of less than 2 years. GBM is characterized by abnormal activation of receptor tyrosine kinase and constitutively activated STAT3. Although EGFR phosphorylation and STAT3 activation are essential for the maintenance of GBM cancer stem cells, the molecular mechanism underlying endosome-mediated STAT3 activation is not fully understood. In ... [more]

Mol. Cancer Ther. Dec. 01, 2014; 13(12);3049-61 [Pubmed: 25313011]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

RRAD

Gene Ontology Molecular Function

GTPase activity [TAS]protein binding [IPI]

EEA1

Gene Ontology Biological Process

Gene Ontology Molecular Function

1-phosphatidylinositol binding [IDA]GTP-dependent protein binding [IDA]calmodulin binding [NAS]protein binding [IPI]protein homodimerization activity [IDA]zinc ion binding [TAS]

Gene Ontology Cellular Component

Reconstituted Complex

Publication

RRAD promotes EGFR-mediated STAT3 activation and induces temozolomide resistance of malignant glioblastoma.

Throughput

Curated By

GTPase activity [TAS]
protein binding [IPI]

1-phosphatidylinositol binding [IDA]
GTP-dependent protein binding [IDA]
calmodulin binding [NAS]
protein binding [IPI]
protein homodimerization activity [IDA]
zinc ion binding [TAS]