PTPRZ1
Gene Ontology Biological Process
- axonal fasciculation [IDA]
- axonogenesis [ISO]
- brain development [IEP]
- hematopoietic progenitor cell differentiation [ISO]
- hippocampus development [IEP]
- learning or memory [ISO, ISS]
- negative regulation of cell proliferation [IMP]
- negative regulation of cell-substrate adhesion [IDA]
- negative regulation of dendrite development [IDA]
- neuron development [IEP]
- oligodendrocyte differentiation [IEP, ISO, ISS]
- peptidyl-tyrosine dephosphorylation [IDA, ISO, ISS]
- positive regulation of Schwann cell migration [IMP]
- positive regulation of cell migration [IDA]
- positive regulation of dendrite development [IDA]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of neuron death [IDA]
- positive regulation of neuron migration [IMP]
- positive regulation of neuron projection development [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- protein dephosphorylation [IDA]
- regulation of dendrite morphogenesis [IMP]
- regulation of oligodendrocyte progenitor proliferation [ISO, ISS]
- visual learning [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DLG4
Gene Ontology Biological Process
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [IMP]
- dendritic spine morphogenesis [IMP, ISO]
- establishment of protein localization [ISO, ISS]
- locomotory exploration behavior [ISO, ISS]
- negative regulation of receptor internalization [IDA]
- neuromuscular process controlling balance [ISO, ISS]
- neuronal ion channel clustering [TAS]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of excitatory postsynaptic membrane potential [IDA]
- positive regulation of synaptic transmission [IDA]
- protein complex assembly [ISO, ISS]
- protein localization to synapse [IMP, ISO]
- receptor localization to synapse [IMP]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IDA]
- regulation of grooming behavior [ISO, ISS]
- regulation of long-term neuronal synaptic plasticity [ISO, ISS]
- social behavior [ISO, ISS]
- synaptic vesicle maturation [ISO, ISS]
- vocalization behavior [ISO, ISS]
Gene Ontology Molecular Function- D1 dopamine receptor binding [IPI]
- P2Y1 nucleotide receptor binding [IPI]
- PDZ domain binding [IPI]
- acetylcholine receptor binding [IDA]
- beta-1 adrenergic receptor binding [IPI]
- glutamate receptor binding [IPI]
- ionotropic glutamate receptor binding [IPI, ISO]
- protein C-terminus binding [IPI, ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- receptor binding [IPI]
- scaffold protein binding [ISO, ISS]
- D1 dopamine receptor binding [IPI]
- P2Y1 nucleotide receptor binding [IPI]
- PDZ domain binding [IPI]
- acetylcholine receptor binding [IDA]
- beta-1 adrenergic receptor binding [IPI]
- glutamate receptor binding [IPI]
- ionotropic glutamate receptor binding [IPI, ISO]
- protein C-terminus binding [IPI, ISO]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- receptor binding [IPI]
- scaffold protein binding [ISO, ISS]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [ISO, ISS]
- cell junction [ISO, ISS]
- cerebellar mossy fiber [ISO]
- cortical cytoskeleton [ISO]
- cytoplasm [ISO, ISS]
- dendrite [ISO]
- dendrite cytoplasm [IDA]
- dendritic spine [ISS]
- endoplasmic reticulum [ISO, ISS]
- excitatory synapse [IDA, ISO]
- extrinsic component of cytoplasmic side of plasma membrane [ISO, ISS]
- ionotropic glutamate receptor complex [ISO, ISS]
- juxtaparanode region of axon [IDA, ISO]
- membrane [IDA, ISO]
- neuron projection terminus [ISO, ISS]
- neuron spine [ISO, ISS]
- neuronal postsynaptic density [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IDA, ISO]
- synapse [IDA, ISO]
- synaptic membrane [ISO]
- synaptic vesicle [ISO, ISS]
- voltage-gated potassium channel complex [IDA]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Tyrosine phosphorylation of ErbB4 is enhanced by PSD95 and repressed by protein tyrosine phosphatase receptor type Z.
Protein tyrosine phosphatase receptor type Z (Ptprz/PTPzeta/RPTPbeta) is a receptor-like protein tyrosine phosphatase (RPTP) preferentially expressed in the brain. ErbB4 is a member of the ErbB-family tyrosine kinases known as a neuregulin (NRG) receptor. Both are known to bind to postsynaptic density-95 (PSD95) on the second and the first/second PDZ (PSD95/Disc large/zona occludens1) domains, respectively, through the PDZ-binding motif of ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PTPRZ1 DLG4 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID