PTPRZ1
Gene Ontology Biological Process
- axonal fasciculation [IDA]
- axonogenesis [ISO]
- brain development [IEP]
- hematopoietic progenitor cell differentiation [ISO]
- hippocampus development [IEP]
- learning or memory [ISO, ISS]
- negative regulation of cell proliferation [IMP]
- negative regulation of cell-substrate adhesion [IDA]
- negative regulation of dendrite development [IDA]
- neuron development [IEP]
- oligodendrocyte differentiation [IEP, ISO, ISS]
- peptidyl-tyrosine dephosphorylation [IDA, ISO, ISS]
- positive regulation of Schwann cell migration [IMP]
- positive regulation of cell migration [IDA]
- positive regulation of dendrite development [IDA]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of neuron death [IDA]
- positive regulation of neuron migration [IMP]
- positive regulation of neuron projection development [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- protein dephosphorylation [IDA]
- regulation of dendrite morphogenesis [IMP]
- regulation of oligodendrocyte progenitor proliferation [ISO, ISS]
- visual learning [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ERBB4
Gene Ontology Biological Process
- cardiac muscle tissue regeneration [ISO, ISS]
- cell fate commitment [ISO]
- cell migration [ISO, ISS]
- central nervous system morphogenesis [ISO, ISS]
- embryonic pattern specification [ISO, ISS]
- heart development [ISO, ISS]
- lactation [ISO, ISS]
- mammary gland alveolus development [ISO, ISS]
- mammary gland development [IEP]
- mammary gland epithelial cell differentiation [ISO, ISS]
- mitochondrial fragmentation involved in apoptotic process [ISO, ISS]
- negative regulation of apoptotic process [ISO, ISS]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of muscle cell apoptotic process [IMP]
- nervous system development [ISO, ISS]
- neural crest cell migration [ISO, ISS]
- odontogenesis [IEP, NAS]
- olfactory bulb interneuron differentiation [ISO, ISS]
- peptidyl-tyrosine phosphorylation [ISO, ISS]
- positive regulation of ERK1 and ERK2 cascade [ISO, ISS]
- positive regulation of STAT protein import into nucleus [ISO, ISS]
- positive regulation of cardiac muscle cell proliferation [ISO, ISS]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [ISO, ISS]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of glucose import [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO, ISS]
- positive regulation of synaptic transmission, GABAergic [IMP]
- positive regulation of transcription, DNA-templated [ISO, ISS]
- positive regulation of tyrosine phosphorylation of Stat5 protein [ISO, ISS]
- protein autophosphorylation [ISO, ISS]
- regulation of cell migration [ISO, ISS]
- response to drug [IEP]
- response to hydrogen peroxide [IEP]
- response to progesterone [IEP]
- signal transduction [ISO]
- surfactant homeostasis [IMP]
- synapse maturation [IMP]
- telencephalon development [IEP]
- transmembrane receptor protein tyrosine kinase signaling pathway [ISO, ISS, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Dephosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Tyrosine phosphorylation of ErbB4 is enhanced by PSD95 and repressed by protein tyrosine phosphatase receptor type Z.
Protein tyrosine phosphatase receptor type Z (Ptprz/PTPzeta/RPTPbeta) is a receptor-like protein tyrosine phosphatase (RPTP) preferentially expressed in the brain. ErbB4 is a member of the ErbB-family tyrosine kinases known as a neuregulin (NRG) receptor. Both are known to bind to postsynaptic density-95 (PSD95) on the second and the first/second PDZ (PSD95/Disc large/zona occludens1) domains, respectively, through the PDZ-binding motif of ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PTPRZ1 ERBB4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - | |
| PTPRZ1 ERBB4 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID