CARTPT
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISS]
- activation of MAPKK activity [ISS]
- adult feeding behavior [ISS]
- cell-cell signaling [TAS]
- cellular glucose homeostasis [IDA]
- cellular response to starvation [ISS]
- circadian regulation of gene expression [ISS]
- negative regulation of appetite [ISS, TAS]
- negative regulation of bone resorption [IMP]
- negative regulation of osteoclast differentiation [TAS]
- positive regulation of blood pressure [IDA]
- positive regulation of epinephrine secretion [IDA]
- positive regulation of transmission of nerve impulse [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SDHB
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Mitochondrial mechanism of neuroprotection by CART.
We previously demonstrated that the neuropeptide cocaine- and amphetamine-regulated transcript (CART) is protective against focal cerebral ischemia in vivo and against neuronal cell death in culture induced by oxygen-glucose deprivation (OGD). The mechanism of neuroprotection by CART is unknown, in part due to lack of knowledge regarding its putative receptor. Using a yeast two-hybrid system with CART's carboxy-terminal to screen ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID