CDC25A
Gene Ontology Biological Process
Gene Ontology Molecular Function
CDK5
Gene Ontology Biological Process
- Schwann cell development [ISO]
- apoptotic process [ISO]
- associative learning [ISO]
- axon extension [TAS]
- axonogenesis [ISO]
- behavioral response to cocaine [ISO]
- calcium ion import [ISO]
- cell migration [ISO]
- cell-matrix adhesion [ISO]
- central nervous system development [TAS]
- central nervous system neuron development [ISO]
- cerebellar cortex development [ISO]
- cerebellar cortex formation [ISO]
- cerebellum development [ISO]
- cerebral cortex development [ISO]
- corpus callosum development [ISO]
- cortical actin cytoskeleton organization [IMP]
- dendrite morphogenesis [ISO]
- exocytosis [IMP]
- forebrain development [ISO]
- hippocampus development [ISO]
- intracellular protein transport [ISO]
- layer formation in cerebral cortex [ISO]
- motor neuron axon guidance [ISO]
- negative regulation of axon extension [ISO]
- negative regulation of cell cycle [ISO]
- negative regulation of neuron death [ISO]
- negative regulation of protein export from nucleus [ISO]
- negative regulation of protein ubiquitination [ISO]
- negative regulation of proteolysis [ISO]
- negative regulation of synaptic plasticity [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- neuron apoptotic process [IMP, ISO]
- neuron differentiation [IDA, ISO]
- neuron migration [ISO]
- neuron projection development [IMP]
- neuron projection morphogenesis [IMP]
- nucleocytoplasmic transport [IMP]
- oligodendrocyte differentiation [ISO]
- peptidyl-serine phosphorylation [IDA, ISO]
- peptidyl-threonine phosphorylation [ISO]
- phosphorylation [ISO]
- positive regulation of calcium ion-dependent exocytosis [ISO]
- positive regulation of neuron apoptotic process [IDA]
- positive regulation of protein binding [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein targeting to membrane [ISO]
- positive regulation of receptor activity [ISO]
- protein autophosphorylation [IDA]
- protein localization to synapse [ISO]
- protein phosphorylation [IDA, ISO]
- receptor catabolic process [ISO]
- receptor clustering [ISO]
- regulated secretory pathway [IMP]
- regulation of cell migration [ISO]
- regulation of dendritic spine morphogenesis [ISO, ISS]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of postsynaptic membrane potential [ISO]
- regulation of synaptic plasticity [IMP]
- response to cocaine [ISO]
- response to wounding [IMP]
- sensory perception of pain [ISO]
- serine phosphorylation of STAT3 protein [ISO]
- skeletal muscle tissue development [IEP, ISO, TAS]
- synapse assembly [ISO]
- synaptic transmission, dopaminergic [ISO]
- synaptic transmission, glutamatergic [ISO]
- synaptic vesicle endocytosis [IMP]
- telencephalon development [ISO]
- visual learning [ISO]
Gene Ontology Molecular Function- ErbB-2 class receptor binding [ISO, ISS]
- ErbB-3 class receptor binding [ISO, ISS]
- acetylcholine receptor activator activity [ISO, ISS]
- cyclin-dependent protein serine/threonine kinase activity [IDA]
- cytoskeletal protein binding [IPI]
- ephrin receptor binding [IPI]
- kinase activity [IDA]
- p53 binding [ISO]
- protein binding [IPI]
- protein kinase activity [IDA, ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISO]
- tau-protein kinase activity [IDA]
- ErbB-2 class receptor binding [ISO, ISS]
- ErbB-3 class receptor binding [ISO, ISS]
- acetylcholine receptor activator activity [ISO, ISS]
- cyclin-dependent protein serine/threonine kinase activity [IDA]
- cytoskeletal protein binding [IPI]
- ephrin receptor binding [IPI]
- kinase activity [IDA]
- p53 binding [ISO]
- protein binding [IPI]
- protein kinase activity [IDA, ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISO]
- tau-protein kinase activity [IDA]
Gene Ontology Cellular Component
- axon [IDA, ISO]
- cell [ISO]
- cell junction [TAS]
- cyclin-dependent protein kinase 5 holoenzyme complex [IDA]
- cytoplasm [IDA, ISO]
- cytoskeleton [IDA]
- cytosol [ISO]
- dendrite [IDA]
- filopodium [ISO]
- growth cone [IDA]
- intracellular [ISO]
- lamellipodium [ISO]
- membrane [IDA]
- neuromuscular junction [IDA]
- neuronal cell body [IDA]
- nucleolus [ISO]
- nucleus [IDA, ISO]
- postsynaptic density [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death.
Aberrant activation of cell cycle proteins is believed to play a critical role in Alzheimer's disease (AD) pathogenesis; although, the molecular mechanisms leading to their activation in diseased neurons remain elusive. The goal of this study was to investigate the mechanistic link between Cdk5 deregulation and cell cycle re-activation in β-amyloid(1-42) (Aβ(1-42))-induced neurotoxicity. Using a chemical genetic approach, we identified ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDK5 CDC25A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID