RTN1
Gene Ontology Biological Process
Gene Ontology Cellular Component
RYR2
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- Purkinje myocyte to ventricular cardiac muscle cell signaling [IMP]
- calcium ion transmembrane transport [IDA, IMP, ISO]
- calcium ion transport [IDA, IMP, IPI, ISO]
- calcium ion transport into cytosol [ISO]
- calcium-mediated signaling [IMP]
- calcium-mediated signaling using intracellular calcium source [ISO]
- canonical Wnt signaling pathway [IDA]
- cardiac muscle contraction [ISO]
- cardiac muscle hypertrophy [IMP]
- cellular calcium ion homeostasis [IMP]
- cellular response to caffeine [IDA, ISO]
- cytosolic calcium ion homeostasis [ISO]
- cytosolic calcium ion transport [IMP]
- detection of calcium ion [ISO]
- embryonic heart tube morphogenesis [IMP]
- establishment of protein localization to endoplasmic reticulum [ISO]
- ion transmembrane transport [ISO]
- left ventricular cardiac muscle tissue morphogenesis [IMP]
- manganese ion transmembrane transport [ISO]
- negative regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of calcium-transporting ATPase activity [ISO]
- positive regulation of heart rate [IMP]
- positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction [IMP]
- positive regulation of sequestering of calcium ion [ISO]
- positive regulation of the force of heart contraction [ISO]
- regulation of cardiac muscle contraction [ISO]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IGI]
- regulation of heart rate [IMP, ISO]
- release of sequestered calcium ion into cytosol [ISO]
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IDA, IMP, ISO]
- response to caffeine [IDA, ISO]
- response to calcium ion [ISO]
- response to hypoxia [IDA]
- response to magnesium ion [ISO]
- response to muscle stretch [ISO]
- response to redox state [ISO]
- sarcoplasmic reticulum calcium ion transport [ISO]
- type B pancreatic cell apoptotic process [IMP, ISO]
- ventricular cardiac muscle cell action potential [IMP]
Gene Ontology Molecular Function- calcium channel activity [IDA]
- calcium-induced calcium release activity [ISO]
- calcium-release channel activity [ISO]
- calmodulin binding [IDA, ISO]
- enzyme binding [IPI, ISO]
- identical protein binding [ISO]
- intracellular ligand-gated calcium channel activity [IDA]
- organic cyclic compound binding [IPI]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase A regulatory subunit binding [ISO]
- protein kinase binding [IPI]
- protein self-association [IMP]
- ryanodine-sensitive calcium-release channel activity [IDA, ISO]
- scaffold protein binding [ISO]
- suramin binding [ISO]
- calcium channel activity [IDA]
- calcium-induced calcium release activity [ISO]
- calcium-release channel activity [ISO]
- calmodulin binding [IDA, ISO]
- enzyme binding [IPI, ISO]
- identical protein binding [ISO]
- intracellular ligand-gated calcium channel activity [IDA]
- organic cyclic compound binding [IPI]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase A regulatory subunit binding [ISO]
- protein kinase binding [IPI]
- protein self-association [IMP]
- ryanodine-sensitive calcium-release channel activity [IDA, ISO]
- scaffold protein binding [ISO]
- suramin binding [ISO]
Gene Ontology Cellular Component
- A band [ISO]
- Z disc [IDA, ISO]
- calcium channel complex [IDA, ISO]
- cell [IMP]
- cytoplasm [ISO]
- cytosol [IMP]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [ISO]
- integral component of membrane [IC]
- intracellular [IGI]
- membrane [IDA, ISO]
- neuron projection [ISO]
- nuclear envelope [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- sarcolemma [ISO]
- sarcomere [IDA]
- sarcoplasmic reticulum [IDA, ISO]
- sarcoplasmic reticulum membrane [IDA, ISO]
- smooth endoplasmic reticulum [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons.
RTN1A is a reticulon protein with predominant localization in the endoplasmic reticulum (ER). It was previously shown that RTN1A is expressed in neurons of the mammalian central nervous system but functional information remains sparse. To elucidate the neuronal function of RTN1A, we chose to focus our investigation on identifying possible novel binding partners specifically interacting with the unique N-terminus of ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RTN1 RYR2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID