BAIT
ELMO1
CED-12, CED12, ELMO-1
engulfment and cell motility 1
GO Process (9)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- Rac protein signal transduction [IGI]
- actin cytoskeleton organization [IGI]
- apoptotic process [NAS]
- cellular component movement [IGI]
- innate immune response [TAS]
- phagocytosis, engulfment [IGI]
- regulation of defense response to virus by virus [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
BAI3
brain-specific angiogenesis inhibitor 3
GO Process (1)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family.
The prototypical DOCK protein, DOCK180, is an evolutionarily conserved Rac regulator and is indispensable during processes such as cell migration and myoblast fusion. The biological activity of DOCK180 is tightly linked to its binding partner ELMO. We previously reported that autoinhibited ELMO proteins regulate signaling from this pathway. One mechanism to activate the ELMO-DOCK180 complex appears to be the recruitment ... [more]
J. Biol. Chem. Nov. 11, 2011; 286(45);38969-79 [Pubmed: 21930703]
Throughput
- Low Throughput
Curated By
- BioGRID