BAIT

ORM2

YLR350W

Protein that mediates sphingolipid homeostasis; evolutionarily conserved, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress; ORM2 has a paralog, ORM1, that arose from the whole genome duplication

GO Process (3)

GO Function (0)

GO Component (3)

Gene Ontology Biological Process

cellular sphingolipid homeostasis [IMP]

negative regulation of sphingolipid biosynthetic process [IGI, IMP]

response to unfolded protein [IMP, ISS]

Gene Ontology Cellular Component

SPOTS complex [IDA]

endoplasmic reticulum [IDA]

integral component of membrane [ISM]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

PREY

ELO3

SUR4, APA1, SRE1, VBM1, fatty acid elongase ELO3, L000002245, YLR372W

Elongase; involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis

GO Process (0)

GO Function (0)

GO Component (0)

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Saccharomyces cerevisiae (S288c)

Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

Membrane engineering of S. cerevisiae targeting sphingolipid metabolism.

Lindahl L, Santos AX, Olsson H, Olsson L, Bettiga M

The sustainable production of fuels and chemicals using microbial cell factories is now well established. However, many microbial production processes are still limited in scale due to inhibition from compounds that are present in the feedstock or are produced during fermentation. Some of these inhibitors interfere with cellular membranes and change the physicochemical properties of the membranes. Another group of ... [more]

Sci Rep Feb. 01, 2017; 7(0);41868 [Pubmed: 28145511]

Throughput

Low Throughput

Ontology Terms

phenotype: vegetative growth (APO:0000106)

Additional Notes

Overexpression of ELO3 and AUR1 together partially rescues growth defect of orm1 orm2 double deletion mutant
genetic complex

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
ELO3 ORM2	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Zimmermann C (2013)	Low	-	BioGRID	1239676

Curated By

BioGRID

Interaction Summary