RTKN
Gene Ontology Biological Process
Gene Ontology Molecular Function
RHOA
Gene Ontology Biological Process
- GTP catabolic process [IDA, ISO]
- actin cytoskeleton organization [ISO, TAS]
- androgen receptor signaling pathway [ISO]
- apical junction assembly [ISO, ISS]
- apolipoprotein A-I-mediated signaling pathway [ISO]
- cell adhesion [ISO]
- cell differentiation [ISO]
- cell morphogenesis [ISO]
- cell-matrix adhesion [ISO]
- cellular response to progesterone stimulus [NAS]
- cerebral cortex cell migration [ISO]
- cleavage furrow formation [ISO, ISS]
- cytoskeleton organization [ISO]
- forebrain radial glial cell differentiation [ISO]
- negative chemotaxis [ISO]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- negative regulation of cell death [IMP]
- negative regulation of intracellular steroid hormone receptor signaling pathway [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of neuron differentiation [IMP]
- neuron projection morphogenesis [IEP]
- ossification involved in bone maturation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO, ISS]
- positive regulation of actin filament polymerization [IMP]
- positive regulation of cell adhesion [IEP]
- positive regulation of cell growth [IEP, IMP]
- positive regulation of cell migration [IEP]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- positive regulation of cytokinesis [ISO, ISS]
- positive regulation of neuron apoptotic process [IMP]
- positive regulation of neuron differentiation [ISO]
- positive regulation of podosome assembly [ISO]
- positive regulation of smooth muscle contraction [IMP]
- positive regulation of stress fiber assembly [ISO]
- positive regulation of translation [IEP]
- positive regulation of vasoconstriction [IEP]
- regulation of actin polymerization or depolymerization [IEP]
- regulation of calcium ion transport [IMP]
- regulation of cell migration [ISO, ISS]
- regulation of dendrite development [IMP]
- regulation of neural precursor cell proliferation [ISO]
- regulation of neuron projection development [ISO]
- regulation of osteoblast proliferation [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO]
- response to amino acid [IEP]
- response to drug [IDA, IEP]
- response to ethanol [IEP]
- response to glucocorticoid [IEP]
- response to glucose [IEP]
- response to hypoxia [IEP]
- response to mechanical stimulus [IEP]
- skeletal muscle tissue development [ISO]
- spindle assembly involved in mitosis [ISO]
- stress fiber assembly [ISO]
- stress-activated protein kinase signaling cascade [IMP]
- substantia nigra development [ISO]
- trabecula morphogenesis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The indolinone MAZ51 induces cell rounding and G2/M cell cycle arrest in glioma cells without the inhibition of VEGFR-3 phosphorylation: involvement of the RhoA and Akt/GSK3β signaling pathways.
MAZ51 is an indolinone-based molecule originally synthesized as a selective inhibitor of vascular endothelial growth factor receptor (VEGFR)-3 tyrosine kinase. This study shows that exposure of two glioma cell lines, rat C6 and human U251MG, to MAZ51 caused dramatic shape changes, including the retraction of cellular protrusions and cell rounding. These changes were caused by the clustering and aggregation of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID