BAIT
RNF138
HSD-4, NARF, STRIN, hNARF, HSD4
ring finger protein 138, E3 ubiquitin protein ligase
GO Process (0)
GO Function (1)
GO Component (1)
Gene Ontology Molecular Function
Homo sapiens
PREY
RBBP4
NURF55, RBAP48, lin-53
retinoblastoma binding protein 4
GO Process (12)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- ATP-dependent chromatin remodeling [IDA]
- CENP-A containing nucleosome assembly [TAS]
- DNA replication-dependent nucleosome assembly [IDA]
- DNA replication-independent nucleosome assembly [IDA]
- G2/M transition of mitotic cell cycle [TAS]
- chromatin assembly [IDA]
- chromatin remodeling [IDA]
- mitotic cell cycle [TAS]
- negative regulation of cell proliferation [TAS]
- nucleosome assembly [TAS]
- regulation of cell cycle [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Ubiquitylation of Rad51d Mediated by E3 Ligase Rnf138 Promotes the Homologous Recombination Repair Pathway.
Ubiquitylation has an important role as a signal transducer that regulates protein function, subcellular localization, or stability during the DNA damage response. In this study, we show that Ring domain E3 ubiquitin ligases RNF138 is recruited to DNA damage site quickly. And the recruitment is mediated through its Zinc finger domains. We further confirm that RNF138 is phosphorylated by ATM ... [more]
PLoS ONE May. 20, 2016; 11(5);e0155476 [Pubmed: 27195665]
Throughput
- Low Throughput
Curated By
- BioGRID