BAIT
USP21
USP16, USP23, RP11-297K8.3
ubiquitin specific peptidase 21
GO Process (5)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability.
USP21 is a centrosome-associated deubiquitylase (DUB) that has been implicated in the formation of primary cilia - crucial organelles for the regulation of the Hedgehog (Hh) signaling pathway in vertebrates. Here, we identify KCTD6 - a cullin-3 E3-ligase substrate adapter that has been previously linked to Hh signaling - as well as Gli1, the key transcription factor responsible for Hh ... [more]
J. Cell. Sci. Nov. 01, 2016; 129(21);4001-4013 [Pubmed: 27621083]
Throughput
- Low Throughput
Curated By
- BioGRID