BAIT
CDC73
C1orf28, FIHP, HPTJT, HRPT1, HRPT2, HYX
cell division cycle 73
GO Process (17)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- cellular response to lipopolysaccharide [ISS]
- endodermal cell fate commitment [ISS]
- histone H2B ubiquitination [IDA]
- histone monoubiquitination [IDA]
- mRNA polyadenylation [IMP]
- negative regulation of G1/S transition of mitotic cell cycle [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of fibroblast proliferation [IMP]
- negative regulation of myeloid cell differentiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of Wnt signaling pathway [IDA]
- positive regulation of mRNA 3'-end processing [IMP]
- positive regulation of transcription elongation from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein destabilization [IMP]
- stem cell maintenance [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
G6PD
G6PD1
glucose-6-phosphate dehydrogenase
GO Process (18)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- NADP metabolic process [IDA]
- NADPH regeneration [IMP]
- carbohydrate metabolic process [TAS]
- cellular response to oxidative stress [IMP]
- cholesterol biosynthetic process [IMP]
- cytokine production [IMP]
- erythrocyte maturation [IMP]
- glucose 6-phosphate metabolic process [IDA, IMP]
- glutathione metabolic process [IMP]
- lipid metabolic process [TAS]
- negative regulation of protein glutathionylation [IMP]
- oxidation-reduction process [IMP]
- pentose biosynthetic process [IDA]
- pentose-phosphate shunt [IDA, TAS]
- pentose-phosphate shunt, oxidative branch [IMP]
- ribose phosphate biosynthetic process [IMP]
- small molecule metabolic process [TAS]
- substantia nigra development [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair.
To identify new regulators of homologous recombination repair, we carried out a genome-wide short-interfering RNA screen combined with ionizing irradiation using RAD51 foci formation as readout. All candidates were confirmed by independent short-interfering RNAs and validated in secondary assays like recombination repair activity and RPA foci formation. Network analysis of the top modifiers identified gene clusters involved in recombination repair ... [more]
Cell Discov Jan. 01, 2015; 1();15034 [Pubmed: 27462432]
Throughput
- High Throughput
Curated By
- BioGRID