BAIT
LNX1
Lnx
ligand of numb-protein X 1
GO Process (3)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
PAFAH1B1
LIS-1, Lis1, MMS10-U, Mdsh, Ms10u, Pafaha, RP23-194P5.2
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
GO Process (35)
GO Function (7)
GO Component (22)
Gene Ontology Biological Process
- acrosome assembly [IMP]
- actin cytoskeleton organization [IMP]
- adult locomotory behavior [IMP, ISO]
- ameboidal-type cell migration [IMP]
- brain morphogenesis [ISO]
- cell migration [IMP]
- cerebral cortex development [IGI, IMP, ISO]
- cerebral cortex neuron differentiation [ISO]
- corpus callosum morphogenesis [ISO]
- establishment of centrosome localization [ISO]
- establishment of mitotic spindle orientation [ISO]
- hippocampus development [IGI, IMP]
- layer formation in cerebral cortex [IGI]
- learning or memory [IMP]
- microtubule cytoskeleton organization [IGI, IMP]
- microtubule organizing center organization [ISO]
- microtubule-based process [ISO]
- negative regulation of JNK cascade [IGI]
- negative regulation of neuron projection development [ISO]
- neuroblast proliferation [IMP]
- neuromuscular process controlling balance [IMP, ISO]
- neuron migration [IGI, IMP, ISO]
- nuclear envelope disassembly [IMP]
- nuclear migration [ISO]
- osteoclast development [IMP]
- positive regulation of axon extension [ISO]
- positive regulation of cytokine-mediated signaling pathway [IMP]
- positive regulation of mitotic cell cycle [ISO]
- protein secretion [IMP]
- regulation of Rho GTPase activity [IMP]
- retrograde axon cargo transport [IDA]
- stem cell division [ISO]
- synaptic transmission [IMP]
- transmission of nerve impulse [IMP]
- vesicle transport along microtubule [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- astral microtubule [ISO]
- axon [ISO]
- cell [IGI]
- cell cortex [ISO]
- cell leading edge [IDA]
- centrosome [IDA, ISO]
- cytoplasm [IDA]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- growth cone [ISO]
- intracellular [IGI]
- kinesin complex [ISO]
- kinetochore [ISO]
- microtubule associated complex [IDA, ISO]
- microtubule cytoskeleton [IDA]
- motile primary cilium [IDA]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nonmotile primary cilium [IDA]
- nuclear envelope [ISO, ISS]
- perinuclear region of cytoplasm [IDA]
- vesicle [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.
NUMB is a key regulator of neurogenesis and neuronal differentiation that can be ubiquitinated and targeted for proteasomal degradation by ligand of numb protein-X (LNX) family E3 ubiquitin ligases. However, our understanding of LNX protein function in vivo is very limited. To examine the role of LNX proteins in regulating NUMB function in vivo, we generated mice lacking both LNX1 ... [more]
Mol. Neurobiol. Nov. 26, 2016; 0(); [Pubmed: 27889896]
Throughput
- High Throughput
Curated By
- BioGRID