BAIT
LNX1
Lnx
ligand of numb-protein X 1
GO Process (3)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
PPP3CA
2900074D19Rik, CN, Caln, Calna, CnA
protein phosphatase 3, catalytic subunit, alpha isoform
GO Process (22)
GO Function (10)
GO Component (9)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- calcineurin-NFAT signaling cascade [IDA, IGI, ISO]
- calcium ion transport [IMP]
- calcium-mediated signaling [IGI]
- cardiac muscle hypertrophy in response to stress [IGI]
- cellular response to drug [ISO]
- cellular response to glucose stimulus [ISO]
- dephosphorylation [IDA]
- multicellular organismal response to stress [IDA]
- negative regulation of chromatin binding [IMP]
- negative regulation of dendrite morphogenesis [IMP]
- negative regulation of insulin secretion [ISO]
- positive regulation of NFAT protein import into nucleus [IDA, IMP, ISO]
- positive regulation of cardiac muscle hypertrophy in response to stress [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- protein dephosphorylation [IMP, ISO]
- protein import into nucleus [IDA]
- regulation of excitatory postsynaptic membrane potential [IGI]
- regulation of synaptic transmission [IMP]
- response to calcium ion [ISO]
- skeletal muscle fiber development [IMP]
- transition between fast and slow fiber [IDA]
Gene Ontology Molecular Function- calcium-dependent protein serine/threonine phosphatase activity [ISO]
- calmodulin binding [ISO]
- calmodulin-dependent protein phosphatase activity [ISO]
- drug binding [ISO]
- enzyme binding [ISO]
- phosphoprotein phosphatase activity [IDA, ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- protein serine/threonine phosphatase activity [ISO]
- calcium-dependent protein serine/threonine phosphatase activity [ISO]
- calmodulin binding [ISO]
- calmodulin-dependent protein phosphatase activity [ISO]
- drug binding [ISO]
- enzyme binding [ISO]
- phosphoprotein phosphatase activity [IDA, ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- protein serine/threonine phosphatase activity [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.
NUMB is a key regulator of neurogenesis and neuronal differentiation that can be ubiquitinated and targeted for proteasomal degradation by ligand of numb protein-X (LNX) family E3 ubiquitin ligases. However, our understanding of LNX protein function in vivo is very limited. To examine the role of LNX proteins in regulating NUMB function in vivo, we generated mice lacking both LNX1 ... [more]
Mol. Neurobiol. Nov. 26, 2016; 0(); [Pubmed: 27889896]
Throughput
- High Throughput
Curated By
- BioGRID