BAIT
LNX1
Lnx
ligand of numb-protein X 1
GO Process (3)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
SRCIN1
P140, SNIP, mKIAA1684, p140Cap, RP23-157O10.7
SRC kinase signaling inhibitor 1
GO Process (7)
GO Function (3)
GO Component (12)
Gene Ontology Biological Process
- negative regulation of cell adhesion [IDA]
- negative regulation of protein secretion [ISO]
- negative regulation of protein tyrosine kinase activity [ISO]
- positive regulation of protein tyrosine kinase activity [ISO]
- regulation of cell migration [ISO]
- regulation of dendritic spine morphogenesis [ISO]
- substrate adhesion-dependent cell spreading [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.
NUMB is a key regulator of neurogenesis and neuronal differentiation that can be ubiquitinated and targeted for proteasomal degradation by ligand of numb protein-X (LNX) family E3 ubiquitin ligases. However, our understanding of LNX protein function in vivo is very limited. To examine the role of LNX proteins in regulating NUMB function in vivo, we generated mice lacking both LNX1 ... [more]
Mol. Neurobiol. Nov. 26, 2016; 0(); [Pubmed: 27889896]
Throughput
- High Throughput
Curated By
- BioGRID