BAIT
LNX1
Lnx
ligand of numb-protein X 1
GO Process (3)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
LDB1
CLIM2, NLI
LIM domain binding 1
GO Process (21)
GO Function (10)
GO Component (4)
Gene Ontology Biological Process
- Wnt signaling pathway [IMP]
- anterior/posterior axis specification [IMP]
- cellular component assembly [IGI]
- cerebellar Purkinje cell differentiation [IMP]
- cerebellum development [IMP]
- epithelial structure maintenance [IGI]
- gastrulation with mouth forming second [IMP]
- hair follicle development [IGI]
- head development [IGI]
- histone H3-K4 acetylation [IMP]
- negative regulation of erythrocyte differentiation [IMP]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of cell adhesion [IGI]
- positive regulation of hemoglobin biosynthetic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP, ISO]
- primitive erythrocyte differentiation [TAS]
- regulation of DNA-templated transcription, elongation [IMP]
- regulation of nucleic acid-templated transcription [IPI]
- somatic stem cell maintenance [IGI]
- transcription from RNA polymerase II promoter [IDA]
- transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- LIM domain binding [IDA, IPI, ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- chromatin binding [IDA]
- enhancer sequence-specific DNA binding [IDA]
- enzyme binding [IPI, ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein self-association [IPI]
- transcription factor binding transcription factor activity [IPI]
- DNA binding [IDA]
- LIM domain binding [IDA, IPI, ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- chromatin binding [IDA]
- enhancer sequence-specific DNA binding [IDA]
- enzyme binding [IPI, ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein self-association [IPI]
- transcription factor binding transcription factor activity [IPI]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.
NUMB is a key regulator of neurogenesis and neuronal differentiation that can be ubiquitinated and targeted for proteasomal degradation by ligand of numb protein-X (LNX) family E3 ubiquitin ligases. However, our understanding of LNX protein function in vivo is very limited. To examine the role of LNX proteins in regulating NUMB function in vivo, we generated mice lacking both LNX1 ... [more]
Mol. Neurobiol. Nov. 26, 2016; 0(); [Pubmed: 27889896]
Throughput
- High Throughput
Curated By
- BioGRID