BAIT
LNX2
9630046H24, AW209022
ligand of numb-protein X 2
GO Process (1)
GO Function (2)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
PRKAR1A
1300018C22Rik, RIalpha, Tse-1, Tse1, RP23-80J21.2
protein kinase, cAMP dependent regulatory, type I, alpha
GO Process (10)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- cardiac muscle cell proliferation [IMP]
- cell proliferation [TAS]
- heart development [IMP]
- mesoderm formation [IMP]
- negative regulation of cAMP-dependent protein kinase activity [ISO]
- negative regulation of protein kinase activity [IMP]
- organ morphogenesis [TAS]
- protein phosphorylation [TAS]
- regulation of protein kinase activity [IGI, ISO]
- sarcomere organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.
NUMB is a key regulator of neurogenesis and neuronal differentiation that can be ubiquitinated and targeted for proteasomal degradation by ligand of numb protein-X (LNX) family E3 ubiquitin ligases. However, our understanding of LNX protein function in vivo is very limited. To examine the role of LNX proteins in regulating NUMB function in vivo, we generated mice lacking both LNX1 ... [more]
Mol. Neurobiol. Nov. 26, 2016; 0(); [Pubmed: 27889896]
Throughput
- High Throughput
Curated By
- BioGRID