BAIT

ATOH1

ATH1, HATH1, MATH-1, bHLHa14
atonal homolog 1 (Drosophila)
GO Process (3)
GO Function (1)
GO Component (1)
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.

Cheng YF, Tong M, Edge AS

Proneural basic helix-loop-helix transcription factor, Atoh1, plays a key role in the development of sensory hair cells. We show here that the level of Atoh1 must be accurately controlled by degradation of the protein in addition to the regulation of Atoh1 gene expression to achieve normal cellular patterning during development of the cochlear sensory epithelium. The stability of Atoh1 was ... [more]

J. Biol. Chem. Sep. 30, 2016; 291(40);21096-21109 [Pubmed: 27542412]

Throughput

  • Low Throughput

Curated By

  • BioGRID