BAIT
ATOH1
ATH1, HATH1, MATH-1, bHLHa14
atonal homolog 1 (Drosophila)
GO Process (3)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
MACF1
ABP620, ACF7, MACF, OFC4
microtubule-actin crosslinking factor 1
GO Process (8)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- ATP catabolic process [ISS]
- Golgi to plasma membrane protein transport [IDA]
- positive regulation of Wnt signaling pathway [ISS]
- positive regulation of axon extension [IDA]
- regulation of epithelial cell migration [ISS]
- regulation of focal adhesion assembly [ISS]
- regulation of microtubule-based process [IMP]
- wound healing [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.
Proneural basic helix-loop-helix transcription factor, Atoh1, plays a key role in the development of sensory hair cells. We show here that the level of Atoh1 must be accurately controlled by degradation of the protein in addition to the regulation of Atoh1 gene expression to achieve normal cellular patterning during development of the cochlear sensory epithelium. The stability of Atoh1 was ... [more]
J. Biol. Chem. Sep. 30, 2016; 291(40);21096-21109 [Pubmed: 27542412]
Throughput
- Low Throughput
Curated By
- BioGRID