BAIT

ATOH1

ATH1, HATH1, MATH-1, bHLHa14

atonal homolog 1 (Drosophila)

GO Process (3)

GO Function (1)

GO Component (1)

Gene Ontology Biological Process

central nervous system development [TAS]

positive regulation of neuron differentiation [ISS]

transcription from RNA polymerase II promoter [TAS]

Gene Ontology Molecular Function

sequence-specific DNA binding transcription factor activity [TAS]

Gene Ontology Cellular Component

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB HPRD

Homo sapiens

PREY

AGO2

EIF2C2, Q10

argonaute RISC catalytic component 2

GO Process (18)

GO Function (7)

GO Component (9)

Gene Ontology Biological Process

Fc-epsilon receptor signaling pathway [TAS]

Notch signaling pathway [TAS]

RNA phosphodiester bond hydrolysis, endonucleolytic [EXP, IDA]

epidermal growth factor receptor signaling pathway [TAS]

fibroblast growth factor receptor signaling pathway [TAS]

gene expression [TAS]

gene silencing by RNA [ISS]

innate immune response [TAS]

mRNA cleavage involved in gene silencing by miRNA [IDA, IMP]

negative regulation of translation involved in gene silencing by miRNA [IDA, IMP]

negative regulation of translational initiation [IDA]

neurotrophin TRK receptor signaling pathway [TAS]

phosphatidylinositol-mediated signaling [TAS]

positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [ISS]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [ISS]

pre-miRNA processing [IDA]

translation [NAS]

translational initiation [NAS]

Gene Ontology Molecular Function

RNA 7-methylguanosine cap binding [IDA]
endoribonuclease activity [EXP]
endoribonuclease activity, cleaving siRNA-paired mRNA [IDA]
poly(A) RNA binding [IDA]
protein binding [IPI]
siRNA binding [IDA]
translation initiation factor activity [NAS]

Gene Ontology Cellular Component

RISC complex [IDA]

cytoplasm [IDA]

cytoplasmic mRNA processing body [IDA]

mRNA cap binding complex [IDA]

micro-ribonucleoprotein complex [IDA]

ribonucleoprotein complex [IDA]

CRISPR Database OMIM VEGA HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.

Cheng YF, Tong M, Edge AS

Proneural basic helix-loop-helix transcription factor, Atoh1, plays a key role in the development of sensory hair cells. We show here that the level of Atoh1 must be accurately controlled by degradation of the protein in addition to the regulation of Atoh1 gene expression to achieve normal cellular patterning during development of the cochlear sensory epithelium. The stability of Atoh1 was ... [more]

J. Biol. Chem. Sep. 30, 2016; 291(40);21096-21109 [Pubmed: 27542412]

Throughput

Low Throughput

Curated By

BioGRID