TLR3
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [TAS]
- I-kappaB phosphorylation [IDA]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of NF-kappaB-inducing kinase activity [NAS]
- cellular response to mechanical stimulus [IEP]
- defense response to bacterium [TAS]
- defense response to virus [TAS]
- detection of virus [NAS]
- extrinsic apoptotic signaling pathway [IDA]
- hyperosmotic response [NAS]
- innate immune response [TAS]
- necroptotic signaling pathway [IDA]
- negative regulation of osteoclast differentiation [NAS]
- positive regulation of NF-kappaB import into nucleus [IDA]
- positive regulation of chemokine production [IDA]
- positive regulation of inflammatory response [IC]
- positive regulation of interferon-alpha biosynthetic process [IDA]
- positive regulation of interferon-beta biosynthetic process [IDA, IMP]
- positive regulation of interferon-beta production [ISS]
- positive regulation of interferon-gamma biosynthetic process [IDA]
- positive regulation of interleukin-12 production [ISS]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of toll-like receptor signaling pathway [IDA]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of tumor necrosis factor production [ISS]
- response to exogenous dsRNA [IDA]
- signal transduction [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SHARPIN
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
--LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation.
The linear ubiquitin chain assembly complex (LUBAC), consisting of SHANK-associated RH-domain-interacting protein (SHARPIN), heme-oxidized IRP2 ubiquitin ligase-1 (HOIL-1), and HOIL-1-interacting protein (HOIP), is a critical regulator of inflammation and immunity. This is highlighted by the fact that patients with perturbed linear ubiquitination caused by mutations in the Hoip or Hoil-1 genes, resulting in knockouts of these proteins, may simultaneously suffer ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID