BAIT
ACTN2
CMD1AA
actinin, alpha 2
GO Process (16)
GO Function (10)
GO Component (11)
Gene Ontology Biological Process
- blood coagulation [TAS]
- cell adhesion [TAS]
- focal adhesion assembly [IMP]
- microspike assembly [IDA]
- muscle filament sliding [TAS]
- negative regulation of potassium ion transmembrane transporter activity [IMP]
- negative regulation of potassium ion transport [IMP]
- negative regulation of protein localization to cell surface [IMP]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of potassium ion transmembrane transporter activity [IDA]
- positive regulation of potassium ion transport [IDA]
- protein homotetramerization [IDA]
- regulation of apoptotic process [NAS]
- regulation of membrane potential [IMP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GATA3
HDR, HDRS
GATA binding protein 3
GO Process (58)
GO Function (13)
GO Component (4)
Gene Ontology Biological Process
- T cell receptor signaling pathway [ISS]
- TOR signaling [ISS]
- anatomical structure formation involved in morphogenesis [ISS]
- anatomical structure morphogenesis [TAS]
- aortic valve morphogenesis [ISS]
- blood coagulation [TAS]
- canonical Wnt signaling pathway involved in metanephric kidney development [ISS]
- cardiac right ventricle morphogenesis [ISS]
- cell fate determination [ISS]
- cellular response to interferon-alpha [IEP]
- cellular response to interleukin-4 [IEP]
- cellular response to tumor necrosis factor [IEP]
- defense response [TAS]
- ear development [IMP]
- kidney development [IMP]
- lymphocyte migration [IDA]
- male gonad development [ISS]
- mesenchymal to epithelial transition [IDA]
- mesonephros development [ISS]
- negative regulation of cell cycle [IMP]
- negative regulation of cell motility [IMP]
- negative regulation of cell proliferation [ISS]
- negative regulation of cell proliferation involved in mesonephros development [ISS]
- negative regulation of endothelial cell apoptotic process [IMP]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation [ISS]
- negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation [ISS]
- negative regulation of inflammatory response [IMP]
- negative regulation of mammary gland epithelial cell proliferation [IDA]
- negative regulation of transcription, DNA-templated [IMP]
- nephric duct formation [ISS]
- nephric duct morphogenesis [ISS]
- norepinephrine biosynthetic process [ISS]
- pharyngeal system development [ISS]
- phosphatidylinositol 3-kinase signaling [ISS]
- positive regulation of T cell differentiation [ISS]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of interleukin-13 secretion [IDA, IMP]
- positive regulation of interleukin-4 production [ISS]
- positive regulation of interleukin-5 secretion [IDA]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of signal transduction [IMP]
- positive regulation of thyroid hormone generation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISS]
- positive regulation of transcription regulatory region DNA binding [IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISS]
- positive regulation of ureteric bud formation [ISS]
- regulation of cellular response to X-ray [IMP]
- regulation of cytokine biosynthetic process [ISS]
- regulation of nephron tubule epithelial cell differentiation [ISS]
- response to estrogen [IEP]
- response to virus [IEP]
- signal transduction [ISS]
- sympathetic nervous system development [ISS]
- transcription from RNA polymerase II promoter [TAS]
- ureteric bud formation [ISS]
- uterus development [ISS]
- ventricular septum development [ISS]
Gene Ontology Molecular Function- DNA binding [TAS]
- E-box binding [IDA]
- HMG box domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IMP]
- core promoter proximal region sequence-specific DNA binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- nucleic acid binding transcription factor activity [IDA, IMP]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- transcription regulatory region sequence-specific DNA binding [IDA]
- DNA binding [TAS]
- E-box binding [IDA]
- HMG box domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IMP]
- core promoter proximal region sequence-specific DNA binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- nucleic acid binding transcription factor activity [IDA, IMP]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- transcription regulatory region sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Widespread macromolecular interaction perturbations in human genetic disorders.
How disease-associated mutations impair protein activities in the context of biological networks remains mostly undetermined. Although a few renowned alleles are well characterized, functional information is missing for over 100,000 disease-associated variants. Here we functionally profile several thousand missense mutations across a spectrum of Mendelian disorders using various interaction assays. The majority of disease-associated alleles exhibit wild-type chaperone binding profiles, ... [more]
Cell Apr. 23, 2015; 161(3);647-60 [Pubmed: 25910212]
Throughput
- High Throughput
Curated By
- BioGRID