ADIPOQ
Gene Ontology Biological Process
- brown fat cell differentiation [ISS]
- cellular response to drug [ISS]
- cellular response to insulin stimulus [ISS]
- detection of oxidative stress [ISS]
- fatty acid beta-oxidation [ISS]
- fatty acid oxidation [ISS]
- generation of precursor metabolites and energy [TAS]
- glucose homeostasis [ISS]
- glucose metabolic process [ISS]
- low-density lipoprotein particle clearance [IDA]
- negative regulation of DNA biosynthetic process [IDA]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of MAP kinase activity [ISS]
- negative regulation of blood pressure [IDA]
- negative regulation of cell migration [ISS]
- negative regulation of fat cell differentiation [IDA]
- negative regulation of gluconeogenesis [ISS]
- negative regulation of granulocyte differentiation [IDA]
- negative regulation of heterotypic cell-cell adhesion [IDA]
- negative regulation of inflammatory response [ISS, NAS]
- negative regulation of intracellular protein transport [IDA]
- negative regulation of low-density lipoprotein particle receptor biosynthetic process [IDA]
- negative regulation of macrophage derived foam cell differentiation [IDA]
- negative regulation of macrophage differentiation [IDA]
- negative regulation of metanephric mesenchymal cell migration [ISS]
- negative regulation of phagocytosis [IDA]
- negative regulation of platelet-derived growth factor receptor signaling pathway [IDA]
- negative regulation of platelet-derived growth factor receptor-alpha signaling pathway [ISS]
- negative regulation of protein autophosphorylation [IDA]
- negative regulation of receptor binding [IDA]
- negative regulation of smooth muscle cell migration [IDA]
- negative regulation of smooth muscle cell proliferation [IDA]
- negative regulation of synaptic transmission [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of tumor necrosis factor production [IDA]
- negative regulation of tumor necrosis factor-mediated signaling pathway [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISS]
- positive regulation of cAMP-dependent protein kinase activity [IDA]
- positive regulation of cellular protein metabolic process [IDA]
- positive regulation of cholesterol efflux [IDA]
- positive regulation of fatty acid metabolic process [ISS]
- positive regulation of glucose import [ISS]
- positive regulation of glycogen (starch) synthase activity [ISS]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of metanephric glomerular visceral epithelial cell development [ISS]
- positive regulation of monocyte chemotactic protein-1 production [IDA]
- positive regulation of myeloid cell apoptotic process [IDA]
- positive regulation of protein kinase A signaling [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of renal albumin absorption [IDA]
- positive regulation of signal transduction [ISS]
- protein homooligomerization [ISS]
- protein localization to plasma membrane [IDA]
- regulation of glucose metabolic process [IDA]
- response to glucose [ISS]
- response to tumor necrosis factor [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SYNE4
Gene Ontology Biological Process
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Widespread macromolecular interaction perturbations in human genetic disorders.
How disease-associated mutations impair protein activities in the context of biological networks remains mostly undetermined. Although a few renowned alleles are well characterized, functional information is missing for over 100,000 disease-associated variants. Here we functionally profile several thousand missense mutations across a spectrum of Mendelian disorders using various interaction assays. The majority of disease-associated alleles exhibit wild-type chaperone binding profiles, ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ADIPOQ SYNE4 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | 2742395 | |
| ADIPOQ SYNE4 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID