BAIT
AGER
RAGE, DAMA-358M23.4
advanced glycosylation end product-specific receptor
GO Process (5)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CREB3
LUMAN, LZIP, sLZIP
cAMP responsive element binding protein 3
GO Process (20)
GO Function (12)
GO Component (12)
Gene Ontology Biological Process
- cytoplasmic sequestering of transcription factor [IDA]
- establishment of viral latency [IDA]
- induction of positive chemotaxis [IDA, IMP]
- negative regulation of cell cycle [NAS]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [IDA]
- negative regulation of ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- positive regulation of calcium ion transport [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of deacetylase activity [IDA]
- positive regulation of defense response to virus by host [IDA]
- positive regulation of monocyte chemotaxis [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of cell growth [IDA]
- regulation of cell proliferation [IMP]
- release from viral latency [IDA, TAS]
- response to endoplasmic reticulum stress [IDA]
- transcription from RNA polymerase II promoter [IDA]
- transcription, DNA-templated [IDA]
Gene Ontology Molecular Function- CCR1 chemokine receptor binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- cAMP response element binding protein binding [IDA]
- chromatin binding [IDA]
- protein binding [IPI]
- protein dimerization activity [TAS]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- CCR1 chemokine receptor binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- cAMP response element binding protein binding [IDA]
- chromatin binding [IDA]
- protein binding [IPI]
- protein dimerization activity [TAS]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
Gene Ontology Cellular Component
- Golgi apparatus [IMP]
- Golgi membrane [IDA]
- cytoplasm [IDA, IMP]
- cytosol [IMP]
- endoplasmic reticulum [IDA, IMP]
- endoplasmic reticulum membrane [IDA]
- integral component of endoplasmic reticulum membrane [IDA]
- integral component of membrane [IDA]
- membrane [IDA]
- neuronal cell body [IDA]
- nuclear body [IDA]
- nucleus [IC, IDA]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Widespread macromolecular interaction perturbations in human genetic disorders.
How disease-associated mutations impair protein activities in the context of biological networks remains mostly undetermined. Although a few renowned alleles are well characterized, functional information is missing for over 100,000 disease-associated variants. Here we functionally profile several thousand missense mutations across a spectrum of Mendelian disorders using various interaction assays. The majority of disease-associated alleles exhibit wild-type chaperone binding profiles, ... [more]
Cell Apr. 23, 2015; 161(3);647-60 [Pubmed: 25910212]
Throughput
- High Throughput
Curated By
- BioGRID