CSNK1E
Gene Ontology Biological Process
- DNA repair [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- Wnt signaling pathway [IBA]
- circadian regulation of gene expression [ISS]
- endocytosis [IBA]
- mitotic cell cycle [TAS]
- peptidyl-serine phosphorylation [IBA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISS]
- protein phosphorylation [IDA, ISS]
- regulation of cell shape [IBA]
- regulation of circadian rhythm [ISS]
- signal transduction [TAS]
Gene Ontology Molecular Function
DVL3
Gene Ontology Biological Process
- Wnt signaling pathway [IDA]
- Wnt signaling pathway, planar cell polarity pathway [IDA]
- canonical Wnt signaling pathway [IDA, IMP]
- non-canonical Wnt signaling pathway [IMP]
- non-canonical Wnt signaling pathway via JNK cascade [ISS]
- planar cell polarity pathway involved in neural tube closure [IBA]
- positive regulation of JUN kinase activity [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of transcription, DNA-templated [IDA]
Gene Ontology Molecular Function
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Widespread macromolecular interaction perturbations in human genetic disorders.
How disease-associated mutations impair protein activities in the context of biological networks remains mostly undetermined. Although a few renowned alleles are well characterized, functional information is missing for over 100,000 disease-associated variants. Here we functionally profile several thousand missense mutations across a spectrum of Mendelian disorders using various interaction assays. The majority of disease-associated alleles exhibit wild-type chaperone binding profiles, ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DVL3 CSNK1E | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | 2734427 | |
| CSNK1E DVL3 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID