BAIT
IL1A
IL-1A, IL1, IL1-ALPHA, IL1F1
interleukin 1, alpha
GO Process (16)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- apoptotic process [TAS]
- cell proliferation [TAS]
- cellular response to heat [IDA]
- cytokine-mediated signaling pathway [IMP]
- inflammatory response [TAS]
- negative regulation of cell proliferation [IDA]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [TAS]
- positive regulation of ERK1 and ERK2 cascade [IBA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IBA]
- positive regulation of JNK cascade [IBA]
- positive regulation of angiogenesis [ISS]
- positive regulation of cytokine secretion [IDA]
- positive regulation of interleukin-2 biosynthetic process [IMP]
- positive regulation of mitosis [IMP]
- positive regulation vascular endothelial growth factor production [ISS]
- response to copper ion [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
KPNA6
IPOA7, KPNA7, RP4-622L5.1
karyopherin alpha 6 (importin alpha 7)
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Widespread macromolecular interaction perturbations in human genetic disorders.
How disease-associated mutations impair protein activities in the context of biological networks remains mostly undetermined. Although a few renowned alleles are well characterized, functional information is missing for over 100,000 disease-associated variants. Here we functionally profile several thousand missense mutations across a spectrum of Mendelian disorders using various interaction assays. The majority of disease-associated alleles exhibit wild-type chaperone binding profiles, ... [more]
Cell Apr. 23, 2015; 161(3);647-60 [Pubmed: 25910212]
Throughput
- High Throughput
Curated By
- BioGRID