PLN
Gene Ontology Biological Process
- blood circulation [NAS]
- cytosolic calcium ion homeostasis [IC]
- negative regulation of ATPase activity [IDA, ISS]
- negative regulation of calcium ion binding [IDA, ISS]
- negative regulation of calcium ion import [ISS]
- negative regulation of calcium ion import into sarcoplasmic reticulum [ISS]
- negative regulation of calcium ion transmembrane transporter activity [IDA, ISS]
- negative regulation of calcium ion transport [IDA]
- negative regulation of calcium-transporting ATPase activity [IDA]
- negative regulation of catalytic activity [ISS]
- negative regulation of heart rate [IMP]
- regulation of calcium ion transport [IDA, ISS]
- regulation of calcium-transporting ATPase activity [IDA]
- regulation of cardiac muscle cell contraction [IC]
- regulation of cardiac muscle cell membrane potential [IC]
- regulation of heart contraction [IMP]
- regulation of relaxation of cardiac muscle [IC]
- regulation of the force of heart contraction [IC]
- relaxation of cardiac muscle [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
EDA
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Widespread macromolecular interaction perturbations in human genetic disorders.
How disease-associated mutations impair protein activities in the context of biological networks remains mostly undetermined. Although a few renowned alleles are well characterized, functional information is missing for over 100,000 disease-associated variants. Here we functionally profile several thousand missense mutations across a spectrum of Mendelian disorders using various interaction assays. The majority of disease-associated alleles exhibit wild-type chaperone binding profiles, ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PLN EDA | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - | |
| EDA PLN | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | 2733477 | |
| EDA PLN | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID