BAIT
PPARG
Nr1c3, PPAR-gamma, PPAR-gamma2, PPARgamma, PPARgamma2
peroxisome proliferator activated receptor gamma
GO Process (55)
GO Function (19)
GO Component (5)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- brown fat cell differentiation [IDA]
- cell fate commitment [IGI]
- cell maturation [ISO]
- cellular response to insulin stimulus [ISO]
- cellular response to lithium ion [IDA]
- cellular response to organic cyclic compound [IDA]
- epithelial cell differentiation [IGI]
- fat cell differentiation [IDA, IGI]
- fatty acid oxidation [ISO]
- glucose homeostasis [ISO]
- inflammatory response [TAS]
- intracellular receptor signaling pathway [TAS]
- lipoprotein transport [ISO]
- long-chain fatty acid transport [IMP]
- low-density lipoprotein particle receptor biosynthetic process [ISO]
- monocyte differentiation [ISO]
- negative regulation of acute inflammatory response [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of cellular response to insulin stimulus [IMP]
- negative regulation of cholesterol storage [ISO]
- negative regulation of collagen biosynthetic process [ISO]
- negative regulation of cytokine production [IMP]
- negative regulation of interferon-gamma-mediated signaling pathway [ISO]
- negative regulation of macrophage derived foam cell differentiation [ISO]
- negative regulation of pancreatic stellate cell proliferation [ISO]
- negative regulation of peptide hormone secretion [IMP]
- negative regulation of receptor biosynthetic process [ISO]
- negative regulation of sequestering of triglyceride [ISO]
- negative regulation of smooth muscle cell proliferation [ISO]
- negative regulation of telomerase activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- peroxisome proliferator activated receptor signaling pathway [ISO]
- placenta development [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of fat cell differentiation [IDA, IGI, IMP, ISO]
- positive regulation of fatty acid oxidation [ISO]
- positive regulation of oligodendrocyte differentiation [ISO]
- positive regulation of phagocytosis, engulfment [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of blood pressure [ISO]
- regulation of fat cell differentiation [IDA, IGI, ISO]
- regulation of lipid metabolic process [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO, TAS]
- regulation of transcription involved in cell fate commitment [IMP]
- response to lipid [IDA]
- response to low-density lipoprotein particle [ISO]
- response to retinoic acid [IDA, ISO]
- signal transduction [ISO]
- transcription from RNA polymerase II promoter [IDA]
- white fat cell differentiation [IDA]
Gene Ontology Molecular Function- DNA binding [IDA, IPI, ISO]
- RNA polymerase II regulatory region DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- WW domain binding [ISO]
- activating transcription factor binding [ISO]
- arachidonic acid binding [IDA]
- chromatin binding [IDA]
- drug binding [ISO]
- enzyme binding [ISO]
- estrogen receptor binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO, TAS]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA, ISO]
- protein binding [IPI]
- protein phosphatase binding [ISO]
- retinoid X receptor binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA, ISO]
- DNA binding [IDA, IPI, ISO]
- RNA polymerase II regulatory region DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- WW domain binding [ISO]
- activating transcription factor binding [ISO]
- arachidonic acid binding [IDA]
- chromatin binding [IDA]
- drug binding [ISO]
- enzyme binding [ISO]
- estrogen receptor binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO, TAS]
- ligand-dependent nuclear receptor transcription coactivator activity [IDA, ISO]
- protein binding [IPI]
- protein phosphatase binding [ISO]
- retinoid X receptor binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [IDA, ISO]
Mus musculus
PREY
ADAM22
ADAM 22, MDC2
ADAM metallopeptidase domain 22
GO Process (2)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
F-box only protein 9 is an E3 ubiquitin ligase of PPARγ.
Peroxisome proliferator-activated receptor gamma (PPARγ) is a critical regulator of carbohydrate and lipid metabolism, adipocyte differentiation and inflammatory response. Post-translational modification of PPARγ and its degradation involve several pathways, including the ubiquitin-proteasome system. Here, we identified F-box only protein 9 (FBXO9) as an E3 ubiquitin ligase of PPARγ. We screened interacting partners of PPARγ using immunoprecipitation and mass spectrometric analysis ... [more]
Exp. Mol. Med. May. 20, 2016; 48();e234 [Pubmed: 27197753]
Throughput
- Low Throughput
Curated By
- BioGRID