BAIT

MAPT

DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU
microtubule-associated protein tau
Homo sapiens
PREY

TUBA4A

H2-ALPHA, TUBA1
tubulin, alpha 4a
Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Microtubule-associated protein tau in human prostate cancer cells: isoforms, phosphorylation, and interactions.

Souter S, Lee G

Tau is a microtubule-associated protein whose function has been investigated primarily in neurons. Recently, tau expression has been correlated with increased drug resistance in various cancers of non-neuronal tissues. In this report, we investigate the tau expressed in cancerous prostate lines ALVA-31, DU 145, and PC-3. Prostate cancer tau is heat-stable and highly phosphorylated, containing many of the modifications identified ... [more]

J. Cell. Biochem. Oct. 15, 2009; 108(3);555-64 [Pubmed: 19681044]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
MAPT TUBA4A
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High-BioGRID
-
TUBA4A MAPT
Co-crystal Structure
Co-crystal Structure

Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.

Low-BioGRID
956920

Curated By

  • BioGRID