APBB1
Gene Ontology Biological Process
- axon guidance [ISO]
- cell cycle arrest [ISO, ISS]
- cellular response to DNA damage stimulus [ISO]
- double-strand break repair [IMP, ISO]
- extracellular matrix organization [ISO]
- histone H4 acetylation [IMP]
- negative regulation of cell growth [ISO, ISS]
- negative regulation of neuron differentiation [ISO]
- negative regulation of thymidylate synthase biosynthetic process [ISO, ISS]
- neuron migration [ISO]
- positive regulation of DNA repair [IMP, ISO]
- positive regulation of apoptotic process [ISO, ISS]
- positive regulation of protein secretion [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of transcription, DNA-templated [ISO, ISS]
- response to iron ion [IEP]
- visual learning [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ENAH
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
A single point mutation in a group I WW domain shifts its specificity to that of group II WW domains.
WW domains can be divided into three groups based on their binding specificity. By random mutagenesis, we switched the specificity of the Yes-associated protein (YAP) WW1 domain, a Group I WW domain, to that of the FE65 WW domain, which belongs to Group II. We showed that a single mutation, leucine 190 (betaB5) to tryptophan, is required to switch from ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID