BAIT
HYPK
C15orf63, HSPC136
huntingtin interacting protein K
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
GLUD1
GDH, GDH1, GLUD
glutamate dehydrogenase 1
GO Process (9)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- cellular amino acid biosynthetic process [TAS]
- cellular nitrogen compound metabolic process [TAS]
- glutamate biosynthetic process [IDA]
- glutamate catabolic process [IDA]
- glutamine metabolic process [ISS]
- positive regulation of insulin secretion [IMP]
- small molecule metabolic process [TAS]
- substantia nigra development [IEP]
- tricarboxylic acid metabolic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of HYPK-interacting proteins reveals involvement of HYPK in regulating cell growth, cell cycle, unfolded protein response and cell death.
Huntingtin Yeast Two-Hybrid Protein K (HYPK) is an intrinsically unstructured huntingtin (HTT)-interacting protein with chaperone-like activity. To obtain more information about the function(s) of the protein, we identified 27 novel interacting partners of HYPK by pull-down assay coupled with mass spectrometry and, further, 9 proteins were identified by co-localization and co-immunoprecipitation (co-IP) assays. In neuronal cells, (EEF1A1 and HSPA1A), (HTT ... [more]
PLoS ONE Dec. 29, 2012; 7(12);e51415 [Pubmed: 23272104]
Throughput
- Low Throughput
Curated By
- BioGRID