BAIT

CLCN2

AL118368, ClC-2, Clc2, nmf240, RP23-101H1.9
chloride channel 2
Mus musculus
PREY

STIP1

stress-induced phosphoprotein 1
GO Process (0)
GO Function (4)
GO Component (2)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Rattus norvegicus

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β.

Peng YJ, Huang JJ, Wu HH, Hsieh HY, Wu CY, Chen SC, Chen TY, Tang CY

Mutations in human CLC-1 chloride channel are associated with the skeletal muscle disorder myotonia congenita. The disease-causing mutant A531V manifests enhanced proteasomal degradation of CLC-1. We recently found that CLC-1 degradation is mediated by cullin 4 ubiquitin ligase complex. It is currently unclear how quality control and protein degradation systems coordinate with each other to process the biosynthesis of CLC-1. ... [more]

Sci Rep Sep. 01, 2016; 6();32444 [Pubmed: 27580824]

Throughput

  • Low Throughput

Curated By

  • BioGRID