BCL10
Gene Ontology Biological Process
- B cell apoptotic process [IDA, IMP]
- I-kappaB kinase/NF-kappaB signaling [IMP, ISO]
- T cell apoptotic process [IDA, IMP]
- T cell receptor signaling pathway [ISO]
- activation of JUN kinase activity [ISA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISA]
- cell death [ISO]
- cellular defense response [IMP]
- fibroblast apoptotic process [IMP]
- immunoglobulin mediated immune response [IMP]
- mast cell activation [NAS]
- negative regulation of mature B cell apoptotic process [ISO]
- neural tube closure [IMP]
- positive regulation of NF-kappaB transcription factor activity [IMP, ISA]
- positive regulation of T cell activation [IMP]
- positive regulation of apoptotic process [ISA, ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of execution phase of apoptosis [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [IDA, ISO]
- positive regulation of interleukin-8 biosynthetic process [ISO]
- positive regulation of phosphorylation [ISO]
- positive regulation of protein ubiquitination [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein heterooligomerization [ISO]
- protein homooligomerization [IMP]
- protein oligomerization [ISO]
- regulation of T cell receptor signaling pathway [IMP]
- response to food [ISO]
- response to fungus [IMP]
- thymocyte apoptotic process [IMP]
Gene Ontology Molecular Function- NF-kappaB binding [IBA, ISO]
- cysteine-type endopeptidase activator activity involved in apoptotic process [ISA]
- enzyme binding [ISO]
- kinase activator activity [ISO]
- kinase binding [ISO]
- protease binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISA]
- protein homodimerization activity [ISA]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- protein self-association [ISO]
- transcription coactivator activity [ISO]
- transcription factor binding [ISO]
- ubiquitin binding [ISO]
- ubiquitin protein ligase binding [ISO]
- NF-kappaB binding [IBA, ISO]
- cysteine-type endopeptidase activator activity involved in apoptotic process [ISA]
- enzyme binding [ISO]
- kinase activator activity [ISO]
- kinase binding [ISO]
- protease binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISA]
- protein homodimerization activity [ISA]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- protein self-association [ISO]
- transcription coactivator activity [ISO]
- transcription factor binding [ISO]
- ubiquitin binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- CBM complex [IBA]
- T cell receptor complex [ISO]
- cytoplasm [IDA, ISA, ISO]
- cytoplasmic microtubule [ISO]
- cytosol [IDA, ISO]
- immunological synapse [IDA]
- intracellular [IMP]
- lipopolysaccharide receptor complex [ISO]
- lysosome [ISO]
- membrane raft [IDA]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- protein complex [ISO]
CARD11
Gene Ontology Biological Process
- T cell costimulation [ISO]
- positive regulation of B cell proliferation [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of T cell activation [IMP]
- positive regulation of T cell proliferation [IMP]
- positive regulation of cytokine production [ISO]
- positive regulation of interleukin-2 biosynthetic process [IMP]
- regulation of B cell differentiation [IMP]
- regulation of T cell differentiation [IMP]
- regulation of immune response [IMP]
- signal transduction [IDA]
- thymic T cell selection [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKCβ Kinase Activity.
To achieve a durable adaptive immune response, lymphocytes must undergo clonal expansion and induce a survival program that enables the persistence of Ag-experienced cells and the development of memory. During the priming phase of this response, CD4(+)T lymphocytes either remain tolerized or undergo clonal expansion. In this article, we show that Usp9X functions as a positive regulatory switch during T ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CARD11 BCL10 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.97 | BioGRID | 2678260 |
Curated By
- BioGRID