PRKCB
Gene Ontology Biological Process
- B cell activation [IMP]
- B cell receptor signaling pathway [IMP]
- calcium ion transport [IDA]
- cellular calcium ion homeostasis [IDA]
- cellular response to carbohydrate stimulus [IDA]
- histone H3-T6 phosphorylation [ISO]
- negative regulation of glucose transport [IMP]
- negative regulation of insulin receptor signaling pathway [ISO]
- positive regulation of B cell receptor signaling pathway [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IMP]
- protein phosphorylation [IDA]
- regulation of dopamine secretion [ISO]
- regulation of growth [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO]
- response to drug [ISO]
- response to hypoxia [IDA]
Gene Ontology Molecular Function- androgen receptor binding [ISO]
- calcium channel regulator activity [IDA]
- chromatin binding [ISO]
- histone binding [ISO]
- histone kinase activity (H3-T6 specific) [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO]
- protein binding [IPI]
- protein kinase C activity [IDA, ISO]
- protein kinase C binding [ISO]
- protein serine/threonine kinase activity [IDA]
- androgen receptor binding [ISO]
- calcium channel regulator activity [IDA]
- chromatin binding [ISO]
- histone binding [ISO]
- histone kinase activity (H3-T6 specific) [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO]
- protein binding [IPI]
- protein kinase C activity [IDA, ISO]
- protein kinase C binding [ISO]
- protein serine/threonine kinase activity [IDA]
Gene Ontology Cellular Component
USP9X
Gene Ontology Biological Process
- BMP signaling pathway [ISO]
- axon extension [IMP, ISO]
- cellular response to transforming growth factor beta stimulus [IMP]
- cerebellar cortex structural organization [IMP]
- hippocampus development [IMP]
- in utero embryonic development [IGI]
- neuron migration [IMP, ISO]
- neuron projection extension [IGI]
- post-embryonic development [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IBA, ISO]
- regulation of proteasomal protein catabolic process [IBA]
- transforming growth factor beta receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKCβ Kinase Activity.
To achieve a durable adaptive immune response, lymphocytes must undergo clonal expansion and induce a survival program that enables the persistence of Ag-experienced cells and the development of memory. During the priming phase of this response, CD4(+)T lymphocytes either remain tolerized or undergo clonal expansion. In this article, we show that Usp9X functions as a positive regulatory switch during T ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID