SETD7
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [ISO]
- heterochromatin organization [IMP, ISO]
- histone lysine methylation [ISO]
- negative regulation of transferase activity [IDA]
- peptidyl-lysine dimethylation [ISO]
- peptidyl-lysine methylation [IDA]
- peptidyl-lysine monomethylation [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of histone H3-K9 methylation [IDA]
Gene Ontology Molecular Function
RNF111
Gene Ontology Biological Process
- pattern specification process [IMP]
- positive regulation of protein ubiquitination [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation of transforming growth factor beta receptor signaling pathway [IDA, IMP]
- protein polyubiquitination [IDA, IGI, IMP]
- protein ubiquitination [ISO]
- ubiquitin-dependent SMAD protein catabolic process [IDA, IMP]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis.
TGF-β signaling regulates a variety of cellular processes, including proliferation, apoptosis, differentiation, immune responses, and fibrogenesis. Here, we describe a lysine methylation-mediated mechanism that controls the pro-fibrogenic activity of TGF-β. We find that the methyltransferase Set9 potentiates TGF-β signaling by targeting Smad7, an inhibitory downstream effector. Smad7 methylation promotes interaction with the E3 ligase Arkadia and, thus, ubiquitination-dependent degradation. Depletion ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID