BAIT
SDC2
HSPG
syndecan 2
GO Process (5)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
NF1
neurofibromin 1
GO Process (66)
GO Function (7)
GO Component (10)
Gene Ontology Biological Process
- MAPK cascade [ISO, ISS]
- Ras protein signal transduction [ISO, ISS]
- Schwann cell development [ISO, ISS]
- actin cytoskeleton organization [ISO, ISS]
- adrenal gland development [ISO, ISS]
- artery morphogenesis [ISO, ISS]
- brain development [ISO, ISS]
- camera-type eye morphogenesis [ISO, ISS]
- cell communication [ISO, ISS]
- cerebral cortex development [ISO, ISS]
- cognition [ISO]
- collagen fibril organization [ISO, ISS]
- extracellular matrix organization [ISO, ISS]
- extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- forebrain astrocyte development [ISO, ISS]
- forebrain morphogenesis [ISO, ISS]
- heart development [ISO, ISS]
- liver development [ISO, ISS]
- metanephros development [ISO, ISS]
- myelination in peripheral nervous system [ISO, ISS]
- negative regulation of MAP kinase activity [ISO, ISS]
- negative regulation of MAPK cascade [ISO, ISS]
- negative regulation of Rac protein signal transduction [ISO]
- negative regulation of Ras protein signal transduction [IBA, ISO]
- negative regulation of angiogenesis [ISO]
- negative regulation of astrocyte differentiation [ISO]
- negative regulation of cell migration [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of cell-matrix adhesion [ISO]
- negative regulation of endothelial cell proliferation [ISO]
- negative regulation of fibroblast proliferation [ISO, ISS]
- negative regulation of neuroblast proliferation [ISO, ISS]
- negative regulation of neurotransmitter secretion [ISO]
- negative regulation of oligodendrocyte differentiation [ISO, ISS]
- negative regulation of osteoclast differentiation [ISO]
- negative regulation of protein kinase activity [ISO, ISS]
- negative regulation of transcription factor import into nucleus [ISO, ISS]
- neural tube development [ISO]
- osteoblast differentiation [ISO, ISS]
- peripheral nervous system development [ISO, ISS]
- phosphatidylinositol 3-kinase signaling [ISO, ISS]
- pigmentation [ISO, ISS]
- positive regulation of Ras GTPase activity [IBA, ISO, ISS]
- positive regulation of adenylate cyclase activity [ISO, ISS]
- positive regulation of apoptotic process [ISO, ISS]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- positive regulation of neuron apoptotic process [ISO, ISS]
- regulation of Ras GTPase activity [IMP, ISO]
- regulation of angiogenesis [ISO, ISS]
- regulation of blood vessel endothelial cell migration [ISO]
- regulation of bone resorption [ISO, ISS]
- regulation of cell proliferation [ISO]
- regulation of cell-matrix adhesion [ISO, ISS]
- regulation of glial cell differentiation [ISO, ISS]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of neuron differentiation [IMP]
- regulation of synaptic transmission, GABAergic [ISO]
- response to hypoxia [ISO, ISS]
- skeletal muscle tissue development [ISO]
- smooth muscle tissue development [ISO, ISS]
- spinal cord development [ISO, ISS]
- sympathetic nervous system development [ISO, ISS]
- visual learning [ISO, ISS]
- wound healing [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Bipartite interaction between neurofibromatosis type I protein (neurofibromin) and syndecan transmembrane heparan sulfate proteoglycans.
The neurofibromatosis type 1 (NF1) gene encodes a large tumor suppressor protein (neurofibromin). Although it is known to possess Ras GTPase-activating protein (GAP) activity, the cellular role of neurofibromin remains unclear. Here we used yeast two-hybrid screening to identify neurofibromin-interacting proteins. Syndecan-2, a transmembrane heparan sulfate proteoglycan (HSPG), was isolated as a binding partner for two distinct regions of the ... [more]
J. Neurosci. Jun. 01, 2001; 21(11);3764-70 [Pubmed: 11356864]
Throughput
- Low Throughput
Curated By
- BioGRID