SDC2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NF1
Gene Ontology Biological Process
- MAPK cascade [ISO, ISS]
- Ras protein signal transduction [ISO, ISS]
- Schwann cell development [ISO, ISS]
- actin cytoskeleton organization [ISO, ISS]
- adrenal gland development [ISO, ISS]
- artery morphogenesis [ISO, ISS]
- brain development [ISO, ISS]
- camera-type eye morphogenesis [ISO, ISS]
- cell communication [ISO, ISS]
- cerebral cortex development [ISO, ISS]
- cognition [ISO]
- collagen fibril organization [ISO, ISS]
- extracellular matrix organization [ISO, ISS]
- extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- forebrain astrocyte development [ISO, ISS]
- forebrain morphogenesis [ISO, ISS]
- heart development [ISO, ISS]
- liver development [ISO, ISS]
- metanephros development [ISO, ISS]
- myelination in peripheral nervous system [ISO, ISS]
- negative regulation of MAP kinase activity [ISO, ISS]
- negative regulation of MAPK cascade [ISO, ISS]
- negative regulation of Rac protein signal transduction [ISO]
- negative regulation of Ras protein signal transduction [IBA, ISO]
- negative regulation of angiogenesis [ISO]
- negative regulation of astrocyte differentiation [ISO]
- negative regulation of cell migration [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of cell-matrix adhesion [ISO]
- negative regulation of endothelial cell proliferation [ISO]
- negative regulation of fibroblast proliferation [ISO, ISS]
- negative regulation of neuroblast proliferation [ISO, ISS]
- negative regulation of neurotransmitter secretion [ISO]
- negative regulation of oligodendrocyte differentiation [ISO, ISS]
- negative regulation of osteoclast differentiation [ISO]
- negative regulation of protein kinase activity [ISO, ISS]
- negative regulation of transcription factor import into nucleus [ISO, ISS]
- neural tube development [ISO]
- osteoblast differentiation [ISO, ISS]
- peripheral nervous system development [ISO, ISS]
- phosphatidylinositol 3-kinase signaling [ISO, ISS]
- pigmentation [ISO, ISS]
- positive regulation of Ras GTPase activity [IBA, ISO, ISS]
- positive regulation of adenylate cyclase activity [ISO, ISS]
- positive regulation of apoptotic process [ISO, ISS]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- positive regulation of neuron apoptotic process [ISO, ISS]
- regulation of Ras GTPase activity [IMP, ISO]
- regulation of angiogenesis [ISO, ISS]
- regulation of blood vessel endothelial cell migration [ISO]
- regulation of bone resorption [ISO, ISS]
- regulation of cell proliferation [ISO]
- regulation of cell-matrix adhesion [ISO, ISS]
- regulation of glial cell differentiation [ISO, ISS]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of neuron differentiation [IMP]
- regulation of synaptic transmission, GABAergic [ISO]
- response to hypoxia [ISO, ISS]
- skeletal muscle tissue development [ISO]
- smooth muscle tissue development [ISO, ISS]
- spinal cord development [ISO, ISS]
- sympathetic nervous system development [ISO, ISS]
- visual learning [ISO, ISS]
- wound healing [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Bipartite interaction between neurofibromatosis type I protein (neurofibromin) and syndecan transmembrane heparan sulfate proteoglycans.
The neurofibromatosis type 1 (NF1) gene encodes a large tumor suppressor protein (neurofibromin). Although it is known to possess Ras GTPase-activating protein (GAP) activity, the cellular role of neurofibromin remains unclear. Here we used yeast two-hybrid screening to identify neurofibromin-interacting proteins. Syndecan-2, a transmembrane heparan sulfate proteoglycan (HSPG), was isolated as a binding partner for two distinct regions of the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID