BAIT

SGTA

SGT, alphaSGT, hSGT
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
GO Process (0)
GO Function (1)
GO Component (1)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

ADRM1

ARM-1, ARM1, GP110
adhesion regulating molecule 1
UPS Project
Homo sapiens

Reconstituted Complex

An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.

Publication

SGTA interacts with the proteasomal ubiquitin receptor Rpn13 via a carboxylate clamp mechanism.

Thapaliya A, Nyathi Y, Martinez-Lumbreras S, Krysztofinska EM, Evans NJ, Terry IL, High S, Isaacson RL

The fate of secretory and membrane proteins that mislocalize to the cytosol is decided by a collaboration between cochaperone SGTA (small, glutamine-rich, tetratricopeptide repeat protein alpha) and the BAG6 complex, whose operation relies on multiple transient and subtly discriminated interactions with diverse binding partners. These include chaperones, membrane-targeting proteins and ubiquitination enzymes. Recently a direct interaction was discovered between SGTA ... [more]

Sci Rep Nov. 09, 2016; 6();36622 [Pubmed: 27827410]

Throughput

  • Low Throughput

Curated By

  • BioGRID