BAIT
GSK3B
glycogen synthase kinase 3 beta
GO Process (35)
GO Function (11)
GO Component (7)
Gene Ontology Biological Process
- ER overload response [IDA]
- Fc-epsilon receptor signaling pathway [TAS]
- axon guidance [TAS]
- canonical Wnt signaling pathway [IC, IDA]
- cellular response to interleukin-3 [ISS]
- circadian rhythm [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- epithelial to mesenchymal transition [IMP]
- extrinsic apoptotic signaling pathway in absence of ligand [ISS]
- fibroblast growth factor receptor signaling pathway [TAS]
- glycogen metabolic process [IDA]
- hippocampus development [IMP]
- innate immune response [TAS]
- intracellular signal transduction [IDA]
- negative regulation of NFAT protein import into nucleus [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of canonical Wnt signaling pathway [TAS]
- negative regulation of glycogen (starch) synthase activity [TAS]
- negative regulation of glycogen biosynthetic process [TAS]
- negative regulation of protein binding [IDA]
- negative regulation of protein complex assembly [IMP]
- negative regulation of type B pancreatic cell development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-serine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of Rac GTPase activity [IMP]
- positive regulation of cell-matrix adhesion [IMP]
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [ISS]
- positive regulation of protein binding [ISS]
- positive regulation of protein catabolic process [IC]
- positive regulation of protein complex assembly [IDA]
- positive regulation of protein export from nucleus [IDA]
- protein phosphorylation [IDA]
- regulation of microtubule-based process [IMP]
- superior temporal gyrus development [IMP]
Gene Ontology Molecular Function- NF-kappaB binding [IPI]
- RNA polymerase II transcription factor binding [IPI]
- beta-catenin binding [IPI]
- kinase activity [IDA, TAS]
- p53 binding [IDA]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISS]
- tau-protein kinase activity [IDA]
- ubiquitin protein ligase binding [IPI]
- NF-kappaB binding [IPI]
- RNA polymerase II transcription factor binding [IPI]
- beta-catenin binding [IPI]
- kinase activity [IDA, TAS]
- p53 binding [IDA]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IPI]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISS]
- tau-protein kinase activity [IDA]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
SOX9
CMD1, CMPD1, SRA1
SRY (sex determining region Y)-box 9
GO Process (70)
GO Function (10)
GO Component (3)
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [ISS]
- Sertoli cell differentiation [ISS]
- cAMP-mediated signaling [IDA]
- cartilage condensation [ISS]
- cartilage development [ISS]
- cell fate specification [ISS]
- cellular response to epidermal growth factor stimulus [ISS]
- cellular response to heparin [ISS]
- cellular response to interleukin-1 [IEP]
- cellular response to mechanical stimulus [ISS]
- cellular response to retinoic acid [IEP]
- cellular response to transforming growth factor beta stimulus [IDA]
- chondrocyte differentiation involved in endochondral bone morphogenesis [IMP]
- chondrocyte hypertrophy [ISS]
- chromatin remodeling [IDA]
- cochlea morphogenesis [ISS]
- endocardial cushion morphogenesis [ISS]
- epidermal growth factor receptor signaling pathway [ISS]
- epithelial cell proliferation involved in prostatic bud elongation [ISS]
- epithelial to mesenchymal transition [ISS]
- hair follicle development [ISS]
- heart valve development [ISS]
- heart valve morphogenesis [ISS]
- intestinal epithelial structure maintenance [ISS]
- male germ-line sex determination [ISS]
- male gonad development [IEP, IMP]
- metanephric nephron tubule formation [ISS]
- morphogenesis of a branching epithelium [ISS]
- negative regulation of apoptotic process [IMP, ISS]
- negative regulation of biomineral tissue development [ISS]
- negative regulation of canonical Wnt signaling pathway [ISS]
- negative regulation of chondrocyte differentiation [ISS]
- negative regulation of epithelial cell proliferation [ISS]
- negative regulation of immune system process [ISS]
- negative regulation of myoblast differentiation [ISS]
- negative regulation of ossification [ISS]
- negative regulation of photoreceptor cell differentiation [ISS]
- negative regulation of transcription, DNA-templated [IMP]
- nucleosome assembly [IDA]
- otic vesicle formation [ISS]
- positive regulation of branching involved in ureteric bud morphogenesis [ISS]
- positive regulation of cartilage development [IDA]
- positive regulation of cell proliferation [IMP]
- positive regulation of chondrocyte differentiation [IDA, IMP]
- positive regulation of epithelial cell differentiation [ISS]
- positive regulation of epithelial cell migration [IMP]
- positive regulation of epithelial cell proliferation [IEP, ISS]
- positive regulation of kidney development [ISS]
- positive regulation of male gonad development [IDA]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of mesenchymal stem cell differentiation [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISS]
- positive regulation of protein phosphorylation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- prostate gland development [IEP]
- protein complex assembly [IDA]
- regulation of apoptotic process [ISS]
- regulation of cell cycle process [IMP]
- regulation of cell proliferation [ISS]
- regulation of cell proliferation involved in tissue homeostasis [ISS]
- renal vesicle induction [ISS]
- retina development in camera-type eye [ISS]
- retinal rod cell differentiation [ISS]
- signal transduction [ISS]
- skeletal system development [IMP]
- somatic stem cell maintenance [ISS]
- spermatogenesis [ISS]
- tissue homeostasis [ISS]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- chromatin binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- enhancer binding [IDA]
- enhancer sequence-specific DNA binding [ISS]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IPI]
- protein kinase activity [ISS]
- sequence-specific DNA binding transcription factor activity [IDA, IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- chromatin binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- enhancer binding [IDA]
- enhancer sequence-specific DNA binding [ISS]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [IPI]
- protein kinase activity [ISS]
- sequence-specific DNA binding transcription factor activity [IDA, IMP]
Gene Ontology Cellular Component
Homo sapiens
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage.
SOX9 encodes a transcription factor that governs cell fate specification throughout development and tissue homeostasis. Elevated SOX9 is implicated in the genesis and progression of human tumors by increasing cell proliferation and epithelial-mesenchymal transition. We found that in response to UV irradiation or genotoxic chemotherapeutics, SOX9 is actively degraded in various cancer types and in normal epithelial cells, through a ... [more]
Nucleic Acids Res. Oct. 14, 2016; 44(18);8855-8869 [Pubmed: 27566146]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SOX9 GSK3B | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID