BAIT
DERL1
DER-1, DER1, UNQ243/PRO276
derlin 1
GO Process (7)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- ER-associated ubiquitin-dependent protein catabolic process [IDA]
- endoplasmic reticulum unfolded protein response [IDA]
- establishment of protein localization [TAS]
- intracellular transport of viral protein in host cell [TAS]
- protein destabilization [IMP]
- response to unfolded protein [IMP]
- retrograde protein transport, ER to cytosol [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EPB41L3
4.1B, DAL-1, DAL1
erythrocyte membrane protein band 4.1-like 3
GO Process (9)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- cortical cytoskeleton organization [TAS]
- cytoskeletal anchoring at plasma membrane [TAS]
- myelin maintenance [ISS]
- neuron projection morphogenesis [ISS]
- paranodal junction assembly [ISS]
- protein localization to juxtaparanode region of axon [ISS]
- protein localization to paranode region of axon [ISS]
- protein localization to plasma membrane [ISS]
- regulation of cell shape [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Derlin-1 promotes ubiquitylation and degradation of the epithelial Na(+) channel, ENaC.
Ubiquitylation of the epithelial Na(+) channel (ENaC) plays a critical role in cellular functions, including transmembrane transport of Na(+), Na(+) and water balance, and blood pressure stabilization. Published studies have suggested that ENaC subunits are targets of ER-related degradation (ERAD) in yeast systems. However, the molecular mechanism underlying proteasome-mediated degradation of ENaC subunits remains to be established. Derlin-1, an E3 ... [more]
J. Cell. Sci. Mar. 15, 2017; 130(6);1027-1036 [Pubmed: 28137758]
Throughput
- Low Throughput
Curated By
- BioGRID