BAIT
DERL1
DER-1, DER1, UNQ243/PRO276
derlin 1
GO Process (7)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- ER-associated ubiquitin-dependent protein catabolic process [IDA]
- endoplasmic reticulum unfolded protein response [IDA]
- establishment of protein localization [TAS]
- intracellular transport of viral protein in host cell [TAS]
- protein destabilization [IMP]
- response to unfolded protein [IMP]
- retrograde protein transport, ER to cytosol [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MDH2
M-MDH, MDH, MGC:3559, MOR1
malate dehydrogenase 2, NAD (mitochondrial)
GO Process (8)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Derlin-1 promotes ubiquitylation and degradation of the epithelial Na(+) channel, ENaC.
Ubiquitylation of the epithelial Na(+) channel (ENaC) plays a critical role in cellular functions, including transmembrane transport of Na(+), Na(+) and water balance, and blood pressure stabilization. Published studies have suggested that ENaC subunits are targets of ER-related degradation (ERAD) in yeast systems. However, the molecular mechanism underlying proteasome-mediated degradation of ENaC subunits remains to be established. Derlin-1, an E3 ... [more]
J. Cell. Sci. Mar. 15, 2017; 130(6);1027-1036 [Pubmed: 28137758]
Throughput
- Low Throughput
Curated By
- BioGRID