BAIT
PML
1200009E24Rik, AI661194, Trim19
promyelocytic leukemia
GO Process (56)
GO Function (9)
GO Component (10)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [IMP]
- PML body organization [IDA, ISO]
- SMAD protein import into nucleus [IMP]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- apoptotic process [ISO]
- branching involved in mammary gland duct morphogenesis [IMP]
- cell aging [IMP]
- cell cycle arrest [IMP, ISO]
- cell fate commitment [IMP]
- cellular response to interleukin-4 [IDA]
- cellular senescence [ISO]
- circadian regulation of gene expression [IDA]
- common-partner SMAD protein phosphorylation [IMP]
- endoplasmic reticulum calcium ion homeostasis [IMP]
- entrainment of circadian clock by photoperiod [IDA]
- extrinsic apoptotic signaling pathway [IMP]
- innate immune response [IDA, ISO]
- intrinsic apoptotic signaling pathway by p53 class mediator [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP, ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IMP]
- intrinsic apoptotic signaling pathway in response to oxidative stress [IMP]
- maintenance of protein location in nucleus [ISO]
- myeloid cell differentiation [IMP]
- negative regulation of angiogenesis [IMP, ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of mitotic cell cycle [ISO]
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- negative regulation of telomerase activity [ISO]
- negative regulation of telomere maintenance via telomerase [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- negative regulation of translation in response to oxidative stress [ISO]
- negative regulation of viral release from host cell [IDA, ISO]
- positive regulation of apoptotic process involved in mammary gland involution [ISO]
- positive regulation of apoptotic signaling pathway [IGI, IMP]
- positive regulation of defense response to virus by host [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [ISO]
- positive regulation of histone deacetylation [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein complex assembly [ISO]
- protein stabilization [ISO]
- protein targeting [ISO]
- regulation of MHC class I biosynthetic process [IDA]
- regulation of calcium ion transport into cytosol [IMP]
- regulation of circadian rhythm [IDA]
- regulation of double-strand break repair [ISO]
- regulation of nucleic acid-templated transcription [TAS]
- regulation of protein phosphorylation [IMP]
- regulation of transcription, DNA-templated [IDA, ISO]
- response to UV [IMP]
- response to cytokine [ISO]
- response to gamma radiation [IMP]
- response to hypoxia [IMP, ISO]
- retinoic acid receptor signaling pathway [IMP]
- transforming growth factor beta receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PIN1
0610025L01Rik, D9Bwg1161e
protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
GO Process (14)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of cell motility [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of transforming growth factor beta receptor signaling pathway [ISO]
- positive regulation of Rho GTPase activity [ISO]
- positive regulation of cell growth involved in cardiac muscle cell development [ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of protein dephosphorylation [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of ubiquitin-protein transferase activity [ISO]
- protein peptidyl-prolyl isomerization [ISO]
- regulation of cell proliferation [IMP]
- regulation of cytokinesis [IMP, ISO]
- regulation of pathway-restricted SMAD protein phosphorylation [ISO]
Gene Ontology Molecular Function
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Manipulating PML SUMOylation via Silencing UBC9 and RNF4 Regulates Cardiac Fibrosis.
The promyelocytic leukemia protein (PML) is essential in the assembly of dynamic subnuclear structures called PML nuclear bodies (PML-NBs), which are involved in regulating diverse cellular functions. However, the possibility of PML being involved in cardiac disease has not been examined. In mice undergoing transverse aortic constriction (TAC) and arsenic trioxide (ATO) injection, transforming growth factor β1 (TGF-β1) was upregulated ... [more]
Mol. Ther. Mar. 01, 2017; 25(3);666-678 [Pubmed: 28143738]
Throughput
- Low Throughput
Curated By
- BioGRID